Cargando…

Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis

[Image: see text] We have obtained the structure of the bacterial diterpene synthase, tuberculosinol/iso-tuberculosinol synthase (Rv3378c) from Mycobacterium tuberculosis, a target for anti-infective therapies that block virulence factor formation. This phosphatase adopts the same fold as found in t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chan, Hsiu-Chien, Feng, Xinxin, Ko, Tzu-Ping, Huang, Chun-Hsiang, Hu, Yumei, Zheng, Yingying, Bogue, Shannon, Nakano, Chiaki, Hoshino, Tsutomu, Zhang, Lilan, Lv, Pin, Liu, Wenting, Crick, Dean C., Liang, Po-Huang, Wang, Andrew H.-J., Oldfield, Eric, Guo, Rey-Ting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986019/ https://www.ncbi.nlm.nih.gov/pubmed/24475925 http://dx.doi.org/10.1021/ja413127v

Ejemplares similares

Substrate-analogue complex structure of Mycobacterium tuberculosis decaprenyl diphosphate synthase
por: Ko, Tzu-Ping, et al.
Publicado: (2019)

Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum
por: Liu, Wenting, et al.
Publicado: (2014)

Decaprenyl Diphosphate Synthase Subunit 1 (PDSS1): A Potential Prognostic Biomarker and Immunotherapy-Target for Hepatocellular Carcinoma
por: Yang, Yuping, et al.
Publicado: (2022)

Farnesyl Diphosphate Synthase Inhibitors from In Silico Screening
por: Lindert, Steffen, et al.
Publicado: (2013)

Undecaprenyl Diphosphate Synthase Inhibitors: Antibacterial Drug Leads
por: Sinko, William, et al.
Publicado: (2014)

Evolution of isoprenyl diphosphate synthase-like terpene synthases in fungi
por: Wei, Guo, et al.
Publicado: (2020)

Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
por: Gabriel, Heloisa B, et al.
Publicado: (2018)

Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness
por: Kim, Hee Yeon, et al.
Publicado: (2018)

Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum
por: Jordão, Fabiana M, et al.
Publicado: (2013)

Functional characterization of ent-copalyl diphosphate synthase, kaurene synthase and kaurene oxidase in the Salvia miltiorrhiza gibberellin biosynthetic pathway
por: Su, Ping, et al.
Publicado: (2016)

Structure and Mechanism of the Diterpene Cyclase ent-Copalyl Diphosphate Synthase
por: Köksal, Mustafa, et al.
Publicado: (2011)

Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors
por: Haney, Staci L., et al.
Publicado: (2017)

Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma
por: Abate, Mario, et al.
Publicado: (2017)

De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug
por: Lancaster, Jason, et al.
Publicado: (2018)

Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells
por: Ory, B, et al.
Publicado: (2008)

Incubation of 2-Methylisoborneol Synthase with the Intermediate Analogue 2-Methylneryl Diphosphate
por: Chou, Wayne K. W., et al.
Publicado: (2017)

Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition
por: Agabiti, Sherry S., et al.
Publicado: (2019)

Biosynthesis of α-Bisabolol by Farnesyl Diphosphate Synthase and α-Bisabolol Synthase and Their Related Transcription Factors in Matricaria recutita L.
por: Tai, Yuling, et al.
Publicado: (2023)

The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection
por: Sleda, Melissa A., et al.
Publicado: (2022)

Bornyl Diphosphate Synthase From Cinnamomum burmanni and Its Application for (+)-Borneol Biosynthesis in Yeast
por: Ma, Rui, et al.
Publicado: (2021)

A Structural and Bioinformatics Investigation of a Fungal Squalene Synthase and Comparisons with Other Membrane Proteins
por: Malwal, Satish R., et al.
Publicado: (2022)

Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma
por: Wang, Xiaoxia, et al.
Publicado: (2018)

The Biosynthetic Gene Cluster for Sestermobaraenes—Discovery of a Geranylfarnesyl Diphosphate Synthase and a Multiproduct Sesterterpene Synthase from Streptomyces mobaraensis
por: Hou, Anwei, et al.
Publicado: (2020)

The essential roles of cytidine diphosphate‐diacylglycerol synthase in bloodstream form Trypanosoma brucei
por: Lilley, Alison C., et al.
Publicado: (2014)

Adaptive evolution of the chrysanthemyl diphosphate synthase gene involved in irregular monoterpene metabolism
por: Liu, Ping-Li, et al.
Publicado: (2012)

Structure Conservation and Differential Expression of Farnesyl Diphosphate Synthase Genes in Euphorbiaceous Plants
por: Guo, Dong, et al.
Publicado: (2015)

Role of Cys73 in the thermostability of farnesyl diphosphate synthase from Geobacillus stearothermophilus
por: Samori, Petrus Yesaya, et al.
Publicado: (2017)

Identification and Molecular Characterization of Geranyl Diphosphate Synthase (GPPS) Genes in Wintersweet Flower
por: Kamran, Hafiz Muhammad, et al.
Publicado: (2020)

Computer-Aided Saturation Mutagenesis of Arabidopsis thaliana Ent-Copalyl Diphosphate Synthase
por: Szymczyk, Piotr, et al.
Publicado: (2019)

Geranylgeranyl diphosphate synthase inhibitor and proteasome inhibitor combination therapy in multiple myeloma
por: Haney, Staci L., et al.
Publicado: (2022)

Functional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl
por: Gong, Daoyong, et al.
Publicado: (2022)

Engineering of a Plant Isoprenyl Diphosphate Synthase for Development of Irregular Coupling Activity
por: Gerasymenko, Iryna, et al.
Publicado: (2021)

Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target
por: Muehlebach, Molly E., et al.
Publicado: (2023)

Structural and functional investigations of syn-copalyl diphosphate synthase from Oryza sativa
por: Ma, Xiaoli, et al.
Publicado: (2023)

Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z-Farnesyl Diphosphate Synthase
por: Chan, Yueh-Te, et al.
Publicado: (2017)

Genome-Wide Identification and Functional Characterization of the Trans-Isopentenyl Diphosphate Synthases Gene Family in Cinnamomum camphora
por: Yang, Zerui, et al.
Publicado: (2021)

Squalene Synthase As a Target for Chagas Disease Therapeutics
por: Shang, Na, et al.
Publicado: (2014)

Decreased expression of prenyl diphosphate synthase subunit 2 correlates with reduced survival of patients with gastric cancer
por: Kanda, Mitsuro, et al.
Publicado: (2014)

Functional analysis and subcellular localization of two geranylgeranyl diphosphate synthases from Penicillium paxilli
por: Saikia, Sanjay, et al.
Publicado: (2009)

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma
por: Haney, Staci L., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_bits79hlkpfocpa8genoo914n9