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A nanotechnological, molecular-modeling, and immunological approach to study the interaction of the anti-tumorigenic peptide p28 with the p53 family of proteins

p28 is an anionic, amphipathic, cell-penetrating peptide derived from the cupredoxin azurin that binds to the DNA-binding domain (DBD) of the tumor suppressor protein, p53, and induces a post-translational increase in the level of wild type and mutated p53 in a wide variety of human cancer cells. As...

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Detalles Bibliográficos
Autores principales: Coppari, Emilia, Yamada, Tohru, Bizzarri, Anna Rita, Beattie, Craig W, Cannistraro, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986302/
https://www.ncbi.nlm.nih.gov/pubmed/24748790
http://dx.doi.org/10.2147/IJN.S58465

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