Dopamine transporter changes after unilateral deep brain stimulation in progressive Parkinson’s disease: a case report

Deep brain stimulation (DBS) at the subthalamic nucleus has been approved as an effective treatment for refractory symptoms of Parkinson’s disease (PD). Studies have shown that bilateral DBS surgery in PD patients results in clinical improvement without reducing dopamine transporter function. Here,...

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Autores principales: Zhang, Huiwei, Wang, Yuanyuan, Liang, Jinchuan, Förster, Stefan, Wu, Ping, Zhao, Jun, Guan, Yihui, Zuo, Chuantao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986415/
https://www.ncbi.nlm.nih.gov/pubmed/24748796
http://dx.doi.org/10.2147/NDT.S59739
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author Zhang, Huiwei
Wang, Yuanyuan
Liang, Jinchuan
Förster, Stefan
Wu, Ping
Zhao, Jun
Guan, Yihui
Zuo, Chuantao
author_facet Zhang, Huiwei
Wang, Yuanyuan
Liang, Jinchuan
Förster, Stefan
Wu, Ping
Zhao, Jun
Guan, Yihui
Zuo, Chuantao
author_sort Zhang, Huiwei
collection PubMed
description Deep brain stimulation (DBS) at the subthalamic nucleus has been approved as an effective treatment for refractory symptoms of Parkinson’s disease (PD). Studies have shown that bilateral DBS surgery in PD patients results in clinical improvement without reducing dopamine transporter function. Here, we report our longitudinal findings in one PD patient, ie, decreases in striatal dopamine transporter binding during one year of follow-up after unilateral DBS at the subthalamic nucleus. Based on this case, we hypothesize that clinical benefit after unilateral DBS may be not directly associated with changes in function at the subthalamic nucleus.
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spelling pubmed-39864152014-04-18 Dopamine transporter changes after unilateral deep brain stimulation in progressive Parkinson’s disease: a case report Zhang, Huiwei Wang, Yuanyuan Liang, Jinchuan Förster, Stefan Wu, Ping Zhao, Jun Guan, Yihui Zuo, Chuantao Neuropsychiatr Dis Treat Case Report Deep brain stimulation (DBS) at the subthalamic nucleus has been approved as an effective treatment for refractory symptoms of Parkinson’s disease (PD). Studies have shown that bilateral DBS surgery in PD patients results in clinical improvement without reducing dopamine transporter function. Here, we report our longitudinal findings in one PD patient, ie, decreases in striatal dopamine transporter binding during one year of follow-up after unilateral DBS at the subthalamic nucleus. Based on this case, we hypothesize that clinical benefit after unilateral DBS may be not directly associated with changes in function at the subthalamic nucleus. Dove Medical Press 2014-04-08 /pmc/articles/PMC3986415/ /pubmed/24748796 http://dx.doi.org/10.2147/NDT.S59739 Text en © 2014 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Report
Zhang, Huiwei
Wang, Yuanyuan
Liang, Jinchuan
Förster, Stefan
Wu, Ping
Zhao, Jun
Guan, Yihui
Zuo, Chuantao
Dopamine transporter changes after unilateral deep brain stimulation in progressive Parkinson’s disease: a case report
title Dopamine transporter changes after unilateral deep brain stimulation in progressive Parkinson’s disease: a case report
title_full Dopamine transporter changes after unilateral deep brain stimulation in progressive Parkinson’s disease: a case report
title_fullStr Dopamine transporter changes after unilateral deep brain stimulation in progressive Parkinson’s disease: a case report
title_full_unstemmed Dopamine transporter changes after unilateral deep brain stimulation in progressive Parkinson’s disease: a case report
title_short Dopamine transporter changes after unilateral deep brain stimulation in progressive Parkinson’s disease: a case report
title_sort dopamine transporter changes after unilateral deep brain stimulation in progressive parkinson’s disease: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986415/
https://www.ncbi.nlm.nih.gov/pubmed/24748796
http://dx.doi.org/10.2147/NDT.S59739
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