Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages

BACKGROUND: Due to the emergency of multidrug-resistant strains of Mycobacterium tuberculosis, is necessary the evaluation of new compounds. FINDINGS: Tedizolid, a novel oxazolidinone, and ACH-702, a new isothiazoloquinolone, were tested against M. tuberculosis infected THP-1 macrophages. These two...

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Autores principales: Molina-Torres, Carmen A, Barba-Marines, Alejandra, Valles-Guerra, Orestes, Ocampo-Candiani, Jorge, Cavazos-Rocha, Norma, Pucci, Michael J, Castro-Garza, Jorge, Vera-Cabrera, Lucio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986449/
https://www.ncbi.nlm.nih.gov/pubmed/24708819
http://dx.doi.org/10.1186/1476-0711-13-13
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author Molina-Torres, Carmen A
Barba-Marines, Alejandra
Valles-Guerra, Orestes
Ocampo-Candiani, Jorge
Cavazos-Rocha, Norma
Pucci, Michael J
Castro-Garza, Jorge
Vera-Cabrera, Lucio
author_facet Molina-Torres, Carmen A
Barba-Marines, Alejandra
Valles-Guerra, Orestes
Ocampo-Candiani, Jorge
Cavazos-Rocha, Norma
Pucci, Michael J
Castro-Garza, Jorge
Vera-Cabrera, Lucio
author_sort Molina-Torres, Carmen A
collection PubMed
description BACKGROUND: Due to the emergency of multidrug-resistant strains of Mycobacterium tuberculosis, is necessary the evaluation of new compounds. FINDINGS: Tedizolid, a novel oxazolidinone, and ACH-702, a new isothiazoloquinolone, were tested against M. tuberculosis infected THP-1 macrophages. These two compounds significantly decreased the number of intracellular mycobacteria at 0.25X, 1X, 4X and 16X the MIC value. The drugs were tested either in nanoparticules or in free solution. CONCLUSION: Tedizolid and ACH-702 have a good intracellular killing activity comparable to that of rifampin or moxifloxacin.
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spelling pubmed-39864492014-04-16 Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages Molina-Torres, Carmen A Barba-Marines, Alejandra Valles-Guerra, Orestes Ocampo-Candiani, Jorge Cavazos-Rocha, Norma Pucci, Michael J Castro-Garza, Jorge Vera-Cabrera, Lucio Ann Clin Microbiol Antimicrob Short Report BACKGROUND: Due to the emergency of multidrug-resistant strains of Mycobacterium tuberculosis, is necessary the evaluation of new compounds. FINDINGS: Tedizolid, a novel oxazolidinone, and ACH-702, a new isothiazoloquinolone, were tested against M. tuberculosis infected THP-1 macrophages. These two compounds significantly decreased the number of intracellular mycobacteria at 0.25X, 1X, 4X and 16X the MIC value. The drugs were tested either in nanoparticules or in free solution. CONCLUSION: Tedizolid and ACH-702 have a good intracellular killing activity comparable to that of rifampin or moxifloxacin. BioMed Central 2014-04-04 /pmc/articles/PMC3986449/ /pubmed/24708819 http://dx.doi.org/10.1186/1476-0711-13-13 Text en Copyright © 2014 Molina-Torres et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Molina-Torres, Carmen A
Barba-Marines, Alejandra
Valles-Guerra, Orestes
Ocampo-Candiani, Jorge
Cavazos-Rocha, Norma
Pucci, Michael J
Castro-Garza, Jorge
Vera-Cabrera, Lucio
Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages
title Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages
title_full Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages
title_fullStr Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages
title_full_unstemmed Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages
title_short Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages
title_sort intracellular activity of tedizolid phosphate and ach-702 versus mycobacterium tuberculosis infected macrophages
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986449/
https://www.ncbi.nlm.nih.gov/pubmed/24708819
http://dx.doi.org/10.1186/1476-0711-13-13
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