New insights into an X-traordinary viral protein

Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and re...

Descripción completa

Detalles Bibliográficos
Autores principales: Schaller, Torsten, Bauby, Hélène, Hué, Stéphane, Malim, Michael H., Goujon, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986551/
https://www.ncbi.nlm.nih.gov/pubmed/24782834
http://dx.doi.org/10.3389/fmicb.2014.00126
_version_ 1782311729557929984
author Schaller, Torsten
Bauby, Hélène
Hué, Stéphane
Malim, Michael H.
Goujon, Caroline
author_facet Schaller, Torsten
Bauby, Hélène
Hué, Stéphane
Malim, Michael H.
Goujon, Caroline
author_sort Schaller, Torsten
collection PubMed
description Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.
format Online
Article
Text
id pubmed-3986551
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-39865512014-04-29 New insights into an X-traordinary viral protein Schaller, Torsten Bauby, Hélène Hué, Stéphane Malim, Michael H. Goujon, Caroline Front Microbiol Microbiology Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein. Frontiers Media S.A. 2014-04-08 /pmc/articles/PMC3986551/ /pubmed/24782834 http://dx.doi.org/10.3389/fmicb.2014.00126 Text en Copyright © 2014 Schaller, Bauby, Hué, Malim and Goujon. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Schaller, Torsten
Bauby, Hélène
Hué, Stéphane
Malim, Michael H.
Goujon, Caroline
New insights into an X-traordinary viral protein
title New insights into an X-traordinary viral protein
title_full New insights into an X-traordinary viral protein
title_fullStr New insights into an X-traordinary viral protein
title_full_unstemmed New insights into an X-traordinary viral protein
title_short New insights into an X-traordinary viral protein
title_sort new insights into an x-traordinary viral protein
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986551/
https://www.ncbi.nlm.nih.gov/pubmed/24782834
http://dx.doi.org/10.3389/fmicb.2014.00126
work_keys_str_mv AT schallertorsten newinsightsintoanxtraordinaryviralprotein
AT baubyhelene newinsightsintoanxtraordinaryviralprotein
AT huestephane newinsightsintoanxtraordinaryviralprotein
AT malimmichaelh newinsightsintoanxtraordinaryviralprotein
AT goujoncaroline newinsightsintoanxtraordinaryviralprotein

Ejemplares similares