Cargando…

Neuropeptide S and BDNF gene expression in the amygdala are influenced by social decision-making under stress

In a newly developed conceptual model of stressful social decision-making, the Stress-Alternatives Model (SAM; used for the 1st time in mice) elicits two types of response: escape or remain submissively. Daily (4d) aggressive social interaction in a neutral arena between a C57BL6/N test mouse and a...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Justin P., Achua, Justin K., Summers, Tangi R., Ronan, Patrick J., Summers, Cliff H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986560/
https://www.ncbi.nlm.nih.gov/pubmed/24782729
http://dx.doi.org/10.3389/fnbeh.2014.00121
_version_ 1782311731582730240
author Smith, Justin P.
Achua, Justin K.
Summers, Tangi R.
Ronan, Patrick J.
Summers, Cliff H.
author_facet Smith, Justin P.
Achua, Justin K.
Summers, Tangi R.
Ronan, Patrick J.
Summers, Cliff H.
author_sort Smith, Justin P.
collection PubMed
description In a newly developed conceptual model of stressful social decision-making, the Stress-Alternatives Model (SAM; used for the 1st time in mice) elicits two types of response: escape or remain submissively. Daily (4d) aggressive social interaction in a neutral arena between a C57BL6/N test mouse and a larger, novel aggressive CD1 mouse, begin after an audible tone (conditioned stimulus; CS). Although escape holes (only large enough for smaller test animals) are available, and the aggressor is unremittingly antagonistic, only half of the mice tested utilize the possibility of escape. During training, for mice that choose to leave the arena and social interaction, latency to escape dramatically decreases over time; this is also true for control C57BL6/N mice which experienced no aggression. Therefore, the open field of the SAM apparatus is intrinsically anxiogenic. It also means that submission to the aggressor is chosen despite this anxiety and the high intensity of the aggressive attacks and defeat. While both groups that received aggression displayed stress responsiveness, corticosterone levels were significantly higher in animals that chose submissive coexistence. Although both escaping and non-escaping groups of animals experienced aggression and defeat, submissive animals also exhibited classic fear conditioning, freezing in response to the CS alone, while escaping animals did not. In the basolateral amygdala (BLA), gene expression of brain-derived neurotrophic factor (BDNF) was diminished, at the same time neuropeptide S (NPS) expression was significantly elevated, but only in submissive animals. This increase in submission-evoked NPS mRNA expression was greatest in the central amygdala (CeA), which coincided with decreased BDNF expression. Reduced expression of BDNF was only found in submissive animals that also exhibit elevated NPS expression, despite elevated corticosterone in all socially interacting animals. The results suggest an interwoven relationship, linked by social context, between amygdalar BDNF, NPS and plasma corticosterone.
format Online
Article
Text
id pubmed-3986560
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-39865602014-04-29 Neuropeptide S and BDNF gene expression in the amygdala are influenced by social decision-making under stress Smith, Justin P. Achua, Justin K. Summers, Tangi R. Ronan, Patrick J. Summers, Cliff H. Front Behav Neurosci Neuroscience In a newly developed conceptual model of stressful social decision-making, the Stress-Alternatives Model (SAM; used for the 1st time in mice) elicits two types of response: escape or remain submissively. Daily (4d) aggressive social interaction in a neutral arena between a C57BL6/N test mouse and a larger, novel aggressive CD1 mouse, begin after an audible tone (conditioned stimulus; CS). Although escape holes (only large enough for smaller test animals) are available, and the aggressor is unremittingly antagonistic, only half of the mice tested utilize the possibility of escape. During training, for mice that choose to leave the arena and social interaction, latency to escape dramatically decreases over time; this is also true for control C57BL6/N mice which experienced no aggression. Therefore, the open field of the SAM apparatus is intrinsically anxiogenic. It also means that submission to the aggressor is chosen despite this anxiety and the high intensity of the aggressive attacks and defeat. While both groups that received aggression displayed stress responsiveness, corticosterone levels were significantly higher in animals that chose submissive coexistence. Although both escaping and non-escaping groups of animals experienced aggression and defeat, submissive animals also exhibited classic fear conditioning, freezing in response to the CS alone, while escaping animals did not. In the basolateral amygdala (BLA), gene expression of brain-derived neurotrophic factor (BDNF) was diminished, at the same time neuropeptide S (NPS) expression was significantly elevated, but only in submissive animals. This increase in submission-evoked NPS mRNA expression was greatest in the central amygdala (CeA), which coincided with decreased BDNF expression. Reduced expression of BDNF was only found in submissive animals that also exhibit elevated NPS expression, despite elevated corticosterone in all socially interacting animals. The results suggest an interwoven relationship, linked by social context, between amygdalar BDNF, NPS and plasma corticosterone. Frontiers Media S.A. 2014-04-08 /pmc/articles/PMC3986560/ /pubmed/24782729 http://dx.doi.org/10.3389/fnbeh.2014.00121 Text en Copyright © 2014 Smith, Achua, Summers, Ronan and Summers. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Smith, Justin P.
Achua, Justin K.
Summers, Tangi R.
Ronan, Patrick J.
Summers, Cliff H.
Neuropeptide S and BDNF gene expression in the amygdala are influenced by social decision-making under stress
title Neuropeptide S and BDNF gene expression in the amygdala are influenced by social decision-making under stress
title_full Neuropeptide S and BDNF gene expression in the amygdala are influenced by social decision-making under stress
title_fullStr Neuropeptide S and BDNF gene expression in the amygdala are influenced by social decision-making under stress
title_full_unstemmed Neuropeptide S and BDNF gene expression in the amygdala are influenced by social decision-making under stress
title_short Neuropeptide S and BDNF gene expression in the amygdala are influenced by social decision-making under stress
title_sort neuropeptide s and bdnf gene expression in the amygdala are influenced by social decision-making under stress
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986560/
https://www.ncbi.nlm.nih.gov/pubmed/24782729
http://dx.doi.org/10.3389/fnbeh.2014.00121
work_keys_str_mv AT smithjustinp neuropeptidesandbdnfgeneexpressionintheamygdalaareinfluencedbysocialdecisionmakingunderstress
AT achuajustink neuropeptidesandbdnfgeneexpressionintheamygdalaareinfluencedbysocialdecisionmakingunderstress
AT summerstangir neuropeptidesandbdnfgeneexpressionintheamygdalaareinfluencedbysocialdecisionmakingunderstress
AT ronanpatrickj neuropeptidesandbdnfgeneexpressionintheamygdalaareinfluencedbysocialdecisionmakingunderstress
AT summerscliffh neuropeptidesandbdnfgeneexpressionintheamygdalaareinfluencedbysocialdecisionmakingunderstress