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Energy demands of diverse spiking cells from the neocortex, hippocampus, and thalamus
It has long been known that neurons in the brain are not physiologically homogeneous. In response to current stimulus, they can fire several distinct patterns of action potentials that are associated with different physiological classes ranging from regular-spiking cells, fast-spiking cells, intrins...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986563/ https://www.ncbi.nlm.nih.gov/pubmed/24782749 http://dx.doi.org/10.3389/fncom.2014.00041 |
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author | Moujahid, Abdelmalik D'Anjou, Alicia Graña, Manuel |
author_facet | Moujahid, Abdelmalik D'Anjou, Alicia Graña, Manuel |
author_sort | Moujahid, Abdelmalik |
collection | PubMed |
description | It has long been known that neurons in the brain are not physiologically homogeneous. In response to current stimulus, they can fire several distinct patterns of action potentials that are associated with different physiological classes ranging from regular-spiking cells, fast-spiking cells, intrinsically bursting cells, and low-threshold cells. In this work we show that the high degree of variability in firing characteristics of action potentials among these cells is accompanied with a significant variability in the energy demands required to restore the concentration gradients after an action potential. The values of the metabolic energy were calculated for a wide range of cell temperatures and stimulus intensities following two different approaches. The first one is based on the amount of Na(+) load crossing the membrane during a single action potential, while the second one focuses on the electrochemical energy functions deduced from the dynamics of the computational neuron models. The results show that the thalamocortical relay neuron is the most energy-efficient cell consuming between 7 and 18 nJ/cm(2) for each spike generated, while both the regular and fast spiking cells from somatosensory cortex and the intrinsically-bursting cell from a cat visual cortex are the least energy-efficient, and can consume up to 100 nJ/cm(2) per spike. The lowest values of these energy demands were achieved at higher temperatures and high external stimuli. |
format | Online Article Text |
id | pubmed-3986563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39865632014-04-29 Energy demands of diverse spiking cells from the neocortex, hippocampus, and thalamus Moujahid, Abdelmalik D'Anjou, Alicia Graña, Manuel Front Comput Neurosci Neuroscience It has long been known that neurons in the brain are not physiologically homogeneous. In response to current stimulus, they can fire several distinct patterns of action potentials that are associated with different physiological classes ranging from regular-spiking cells, fast-spiking cells, intrinsically bursting cells, and low-threshold cells. In this work we show that the high degree of variability in firing characteristics of action potentials among these cells is accompanied with a significant variability in the energy demands required to restore the concentration gradients after an action potential. The values of the metabolic energy were calculated for a wide range of cell temperatures and stimulus intensities following two different approaches. The first one is based on the amount of Na(+) load crossing the membrane during a single action potential, while the second one focuses on the electrochemical energy functions deduced from the dynamics of the computational neuron models. The results show that the thalamocortical relay neuron is the most energy-efficient cell consuming between 7 and 18 nJ/cm(2) for each spike generated, while both the regular and fast spiking cells from somatosensory cortex and the intrinsically-bursting cell from a cat visual cortex are the least energy-efficient, and can consume up to 100 nJ/cm(2) per spike. The lowest values of these energy demands were achieved at higher temperatures and high external stimuli. Frontiers Media S.A. 2014-04-08 /pmc/articles/PMC3986563/ /pubmed/24782749 http://dx.doi.org/10.3389/fncom.2014.00041 Text en Copyright © 2014 Moujahid, D'Anjou and Graña. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Moujahid, Abdelmalik D'Anjou, Alicia Graña, Manuel Energy demands of diverse spiking cells from the neocortex, hippocampus, and thalamus |
title | Energy demands of diverse spiking cells from the neocortex, hippocampus, and thalamus |
title_full | Energy demands of diverse spiking cells from the neocortex, hippocampus, and thalamus |
title_fullStr | Energy demands of diverse spiking cells from the neocortex, hippocampus, and thalamus |
title_full_unstemmed | Energy demands of diverse spiking cells from the neocortex, hippocampus, and thalamus |
title_short | Energy demands of diverse spiking cells from the neocortex, hippocampus, and thalamus |
title_sort | energy demands of diverse spiking cells from the neocortex, hippocampus, and thalamus |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986563/ https://www.ncbi.nlm.nih.gov/pubmed/24782749 http://dx.doi.org/10.3389/fncom.2014.00041 |
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