Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches

BACKGROUND: IL-17A is a pro-inflammatory cytokine that is normally associated with autoimmune arthritis and other pro-inflammatory conditions. Recently, IL-17A has emerged as a critical factor in enhancing breast cancer (BC)-associated metastases. We generated immune competent arthritic mouse models...

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Detalles Bibliográficos
Autores principales: Roy, Lopamudra Das, Sahraei, Mahnaz, Schettini, Jorge L, Gruber, Helen E, Besmer, Dahlia M, Mukherjee, Pinku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986611/
https://www.ncbi.nlm.nih.gov/pubmed/24674692
http://dx.doi.org/10.1186/1471-2407-14-225

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