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Inventing new medicines: The FGF21 story()
Since the discovery of insulin in 1921, protein therapeutics have become vital tools in the treatment of diabetes mellitus. This heritage has been extended with the comparatively recent introduction of recombinant and re-engineered insulins, in addition to the advent of GLP1 agonists. FGF21 represen...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986619/ https://www.ncbi.nlm.nih.gov/pubmed/24749049 http://dx.doi.org/10.1016/j.molmet.2013.12.003 |
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author | Kharitonenkov, Alexei Adams, Andrew C. |
author_facet | Kharitonenkov, Alexei Adams, Andrew C. |
author_sort | Kharitonenkov, Alexei |
collection | PubMed |
description | Since the discovery of insulin in 1921, protein therapeutics have become vital tools in the treatment of diabetes mellitus. This heritage has been extended with the comparatively recent introduction of recombinant and re-engineered insulins, in addition to the advent of GLP1 agonists. FGF21 represents an example of a novel experimental protein therapy which is able to induce favorable metabolic effects in various species ranging from rodents to man. The aim of this review is to communicate the story of the FGF21 drug discovery path from identification in a functional in vitro screen, to the eventual evaluation of its utility in patients. Given that the development of FGF21 advanced hand-in-hand with rapidly evolving scientific research around this target, we have also attempted to describe our view of recent developments regarding the mechanistic understanding of FGF21 biology. |
format | Online Article Text |
id | pubmed-3986619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-39866192014-04-18 Inventing new medicines: The FGF21 story() Kharitonenkov, Alexei Adams, Andrew C. Mol Metab Review Since the discovery of insulin in 1921, protein therapeutics have become vital tools in the treatment of diabetes mellitus. This heritage has been extended with the comparatively recent introduction of recombinant and re-engineered insulins, in addition to the advent of GLP1 agonists. FGF21 represents an example of a novel experimental protein therapy which is able to induce favorable metabolic effects in various species ranging from rodents to man. The aim of this review is to communicate the story of the FGF21 drug discovery path from identification in a functional in vitro screen, to the eventual evaluation of its utility in patients. Given that the development of FGF21 advanced hand-in-hand with rapidly evolving scientific research around this target, we have also attempted to describe our view of recent developments regarding the mechanistic understanding of FGF21 biology. Elsevier 2013-12-27 /pmc/articles/PMC3986619/ /pubmed/24749049 http://dx.doi.org/10.1016/j.molmet.2013.12.003 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Kharitonenkov, Alexei Adams, Andrew C. Inventing new medicines: The FGF21 story() |
title | Inventing new medicines: The FGF21 story() |
title_full | Inventing new medicines: The FGF21 story() |
title_fullStr | Inventing new medicines: The FGF21 story() |
title_full_unstemmed | Inventing new medicines: The FGF21 story() |
title_short | Inventing new medicines: The FGF21 story() |
title_sort | inventing new medicines: the fgf21 story() |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986619/ https://www.ncbi.nlm.nih.gov/pubmed/24749049 http://dx.doi.org/10.1016/j.molmet.2013.12.003 |
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