Cargando…

Quantitative Determination of ABT-925 in Human Plasma by On-Line SPE and LC-MS/MS: Validation and Sample Analysis in Phase II Studies

A fully automated 96-well On-Line Solid Phase Extraction (SPE) followed by High Performance Liquid Chromatography (HPLC)-Tandem Mass Spectrometric (MS/MS) method for the determination of ABT-925 (2-{3-[4-(2-tert-Butyl-6-trifluoromethyl-pyrimidin-4-yl)-piperazin-1-yl)-propyl-sulfanyl}-3H-pyrimidin-4-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wan, Katty, Rieser, Matthew, El-Shourbagy, Tawakol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986714/ https://www.ncbi.nlm.nih.gov/pubmed/27721349 http://dx.doi.org/10.3390/pharmaceutics2020171

Ejemplares similares

Strategies for Developing Sensitive and Automated LC-MS/MS Assays of a Pharmaceutical Compound and Its Metabolite from Whole Blood Matrix
por: Xu, Raymond N., et al.
Publicado: (2010)

LC–MS/MS method for the quantitation of decitabine and venetoclax in rat plasma after SPE: Application to pharmacokinetic study
por: Alnasser, Abdulaziz I., et al.
Publicado: (2023)

Development of a SPE-LC-MS Method for the Quantitation of Palbociclib and Abemaciclib in Human Plasma
por: Calucică, Daniela Maria, et al.
Publicado: (2022)

Rapid SPE – LC MS/MS analysis for atrazine, its by-products, simazine and S metolachlor in groundwater samples
por: Blanchoud, Hélène, et al.
Publicado: (2020)

A Fully Automated Online SPE-LC-MS/MS Method for the Determination of 10 Pharmaceuticals in Wastewater Samples
por: Belay, Masho Hilawie, et al.
Publicado: (2022)

Extraction and Determination of Vitamin K(1) in Foods by Ultrasound-Assisted Extraction, SPE, and LC-MS/MS
por: Xu, Yueqing, et al.
Publicado: (2020)

An Optimized High Throughput Clean-Up Method Using Mixed-Mode SPE Plate for the Analysis of Free Arachidonic Acid in Plasma by LC-MS/MS
por: Wang, Wan, et al.
Publicado: (2015)

Quantitative HPLC-MS analysis of nucleotide sugars in plant cells following off-line SPE sample preparation
por: Behmüller, Robert, et al.
Publicado: (2014)

Off-Line Multidimensional Liquid Chromatography and Auto Sampling Result in Sample Loss in LC/LC–MS/MS
por: Magdeldin, Sameh, et al.
Publicado: (2014)

Bioavailable Sulforaphane Quantitation in Plasma by LC–MS/MS Is Enhanced by Blocking Thiols
por: Grady, Rachel S., et al.
Publicado: (2023)

Comparison of Two Solid-Phase Extraction (SPE) Methods for the Identification and Quantification of Porcine Retinal Protein Markers by LC-MS/MS
por: Schmelter, Carsten, et al.
Publicado: (2018)

An optimized SPE-LC-MS/MS method for antibiotics residue analysis in ground, surface and treated water samples by response surface methodology- central composite design
por: Mirzaei, Roya, et al.
Publicado: (2017)

Development and Optimisation of a Multiresidue Method for the Determination of 40 Anthelmintic Compounds in Environmental Water Samples by Solid Phase Extraction (SPE) with LC-MS/MS Detection
por: Mooney, Damien, et al.
Publicado: (2019)

Simultaneous Quantitation of Isoprenoid Pyrophosphates in Plasma and Cancer Cells Using LC-MS/MS
por: Chhonker, Yashpal S., et al.
Publicado: (2018)

Development of an Improved Method of Sample Extraction and Quantitation of Multi-Mycotoxin in Feed by LC-MS/MS
por: Nakhjavan, Bahar, et al.
Publicado: (2020)

LC–MS/MS assay for quantitation of enalapril and enalaprilat in plasma for bioequivalence study in Indian subjects
por: Halder, Dhiman, et al.
Publicado: (2017)

SPE–UPLC–MS/MS for Determination of 36 Monomers of Alkylphenol Ethoxylates in Tea
por: Lin, Qin, et al.
Publicado: (2023)

Determination of Alternaria Toxins in Tomato, Wheat, and Sunflower Seeds by SPE and LC-MS/MS—A Method Validation Through a Collaborative Trial
por: Gonçalves, Carlos, et al.
Publicado: (2021)

Screening of Novel Antimicrobial Diastereomers of Azithromycin–Thiosemicarbazone Conjugates: A Combined LC-SPE/Cryo NMR, MS/MS and Molecular Modeling Approach
por: Habinovec, Iva, et al.
Publicado: (2022)

Quantitation of cyclic dinucleotides by reversed-phase LC-MS/MS
por: Spangler, Christian, et al.
Publicado: (2009)

Determination of Nine Fentanyl Drugs in Hair Samples by GC-MS/MS and LC-MS/MS
por: Wei, Qi, et al.
Publicado: (2022)

Evaluation of LC-MS and LC×LC-MS in analysis of zebrafish embryo samples for comprehensive lipid profiling
por: Xu, Mengmeng, et al.
Publicado: (2020)

Fast and Sensitive Screening of Oxandrolone and Its Major Metabolite 17-Epi-Oxandrolone in Human Urine by UHPLC—MS/MS with On-Line SPE Sample Pretreatment
por: Galba, Jaroslav, et al.
Publicado: (2021)

Development and validation of Lenalidomide in human plasma by LC-MS/MS
por: Ranganathan, Premanand, et al.
Publicado: (2019)

Using the SPE and Micro-HPLC-MS/MS Method for the Analysis of Betalains in Rat Plasma after Red Beet Administration
por: Sawicki, Tomasz, et al.
Publicado: (2017)

Fast Quantitative LC-MS/MS Determination of Illicit Substances in Solid and Liquid Unknown Seized Samples
por: Merone, Giuseppe M., et al.
Publicado: (2021)

Development of an LC–MS/MS method for the quantitation of deoxyglycychloxazol in rat plasma and its application in pharmacokinetic study()
por: Li, Rongshan, et al.
Publicado: (2016)

Development and Validation of an LC-MS/MS Method for the Quantitative Determination of Contezolid in Human Plasma and Cerebrospinal Fluid
por: Zhang, Guanxuanzi, et al.
Publicado: (2022)

HybridSPE: A novel technique to reduce phospholipid-based matrix effect in LC–ESI-MS Bioanalysis
por: Ahmad, Shafeeque, et al.
Publicado: (2012)

Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum
por: van der Laan, Tom, et al.
Publicado: (2019)

Automatic analytical approach for the determination of 12 illicit drugs and nicotine metabolites in wastewater using on-line SPE-UHPLC-MS/MS
por: Wang, Jingyuan, et al.
Publicado: (2021)

Absolute quantification of endogenous angiotensin II levels in human plasma using ESI-LC-MS/MS
por: Schulz, Anna, et al.
Publicado: (2014)

Determination of Scopolamine Distribution in Plasma and Brain by LC-MS/MS in Rats
por: Chen, Juan, et al.
Publicado: (2022)

Quantitative Analysis of Isoniazid and Its Four Primary Metabolites in Plasma of Tuberculosis Patients Using LC-MS/MS
por: Ky Anh, Nguyen, et al.
Publicado: (2022)

New Method for Simultaneous Determination of Microcystins and Cylindrospermopsin in Vegetable Matrices by SPE-UPLC-MS/MS
por: Díez-Quijada, Leticia, et al.
Publicado: (2018)

Rapid Structure Determination of Bioactive 4″-Tetrahydrofurfuryl Macrozone Reaction Mixture Components by LC-SPE/Cryo NMR and MS
por: Habinovec, Iva, et al.
Publicado: (2021)

A Novel Hybridization LC-MS/MS Methodology for Quantification of siRNA in Plasma, CSF and Tissue Samples
por: Yuan, Long, et al.
Publicado: (2023)

Analysis of Amisulpride in Human Plasma by SPE and LC with Fluorescence Detection
por: Kudris, Illia V., et al.
Publicado: (2011)

Quantitative LC-MS/MS Analysis of Proteins Involved in Metastasis of Breast Cancer
por: Goto, Rieko, et al.
Publicado: (2015)

Dataset of mouse hippocampus profiled by LC–MS/MS for label-free quantitation
por: English, Jane A., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1po3lish91m84nq869l32jcj4f