The Role of Configurational Entropy in Amorphous Systems

Configurational entropy is an important parameter in amorphous systems. It is involved in the thermodynamic considerations, plays an important role in the molecular mobility calculations through its appearance in the Adam-Gibbs equation and provides information on the solubility increase of an amorp...

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Detalles Bibliográficos
Autores principales: Graeser, Kirsten A., Patterson, James E., Zeitler, J. Axel, Rades, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986718/
https://www.ncbi.nlm.nih.gov/pubmed/27721353
http://dx.doi.org/10.3390/pharmaceutics2020224
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author Graeser, Kirsten A.
Patterson, James E.
Zeitler, J. Axel
Rades, Thomas
author_facet Graeser, Kirsten A.
Patterson, James E.
Zeitler, J. Axel
Rades, Thomas
author_sort Graeser, Kirsten A.
collection PubMed
description Configurational entropy is an important parameter in amorphous systems. It is involved in the thermodynamic considerations, plays an important role in the molecular mobility calculations through its appearance in the Adam-Gibbs equation and provides information on the solubility increase of an amorphous form compared to its crystalline counterpart. This paper presents a calorimetric method which enables the scientist to quickly determine the values for the configurational entropy at any temperature and obtain the maximum of information from these measurements.
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spelling pubmed-39867182014-04-15 The Role of Configurational Entropy in Amorphous Systems Graeser, Kirsten A. Patterson, James E. Zeitler, J. Axel Rades, Thomas Pharmaceutics Article Configurational entropy is an important parameter in amorphous systems. It is involved in the thermodynamic considerations, plays an important role in the molecular mobility calculations through its appearance in the Adam-Gibbs equation and provides information on the solubility increase of an amorphous form compared to its crystalline counterpart. This paper presents a calorimetric method which enables the scientist to quickly determine the values for the configurational entropy at any temperature and obtain the maximum of information from these measurements. MDPI 2010-05-25 /pmc/articles/PMC3986718/ /pubmed/27721353 http://dx.doi.org/10.3390/pharmaceutics2020224 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license http://creativecommons.org/licenses/by/3.0/.
spellingShingle Article
Graeser, Kirsten A.
Patterson, James E.
Zeitler, J. Axel
Rades, Thomas
The Role of Configurational Entropy in Amorphous Systems
title The Role of Configurational Entropy in Amorphous Systems
title_full The Role of Configurational Entropy in Amorphous Systems
title_fullStr The Role of Configurational Entropy in Amorphous Systems
title_full_unstemmed The Role of Configurational Entropy in Amorphous Systems
title_short The Role of Configurational Entropy in Amorphous Systems
title_sort role of configurational entropy in amorphous systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986718/
https://www.ncbi.nlm.nih.gov/pubmed/27721353
http://dx.doi.org/10.3390/pharmaceutics2020224
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