Cargando…

8-oxoguanine causes spontaneous de novo germline mutations in mice

Spontaneous germline mutations generate genetic diversity in populations of sexually reproductive organisms, and are thus regarded as a driving force of evolution. However, the cause and mechanism remain unclear. 8-oxoguanine (8-oxoG) is a candidate molecule that causes germline mutations, because i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ohno, Mizuki, Sakumi, Kunihiko, Fukumura, Ryutaro, Furuichi, Masato, Iwasaki, Yuki, Hokama, Masaaki, Ikemura, Toshimichi, Tsuzuki, Teruhisa, Gondo, Yoichi, Nakabeppu, Yusaku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986730/ https://www.ncbi.nlm.nih.gov/pubmed/24732879 http://dx.doi.org/10.1038/srep04689

Ejemplares similares

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction
por: Sampath, Harini, et al.
Publicado: (2012)

8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions
por: Leon, Julio, et al.
Publicado: (2016)

Corrigendum: 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions
por: Leon, Julio, et al.
Publicado: (2016)

MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis
por: Oka, Sugako, et al.
Publicado: (2021)

NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals
por: Abolhassani, Nona, et al.
Publicado: (2010)

Cellular Levels of 8-Oxoguanine in either DNA or the Nucleotide Pool Play Pivotal Roles in Carcinogenesis and Survival of Cancer Cells
por: Nakabeppu, Yusaku
Publicado: (2014)

A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA
por: Ushijima, Yasuhiro, et al.
Publicado: (2005)

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle
por: Vartanian, Vladimir, et al.
Publicado: (2017)

An ENU-induced p.C225S missense mutation in the mouse Tgfb1 gene does not cause Camurati-Engelmann disease-like skeletal phenotypes
por: Ichimura, Satoki, et al.
Publicado: (2016)

Illegitimate translation causes unexpected gene expression from on-target out-of-frame alleles created by CRISPR-Cas9
por: Makino, Shigeru, et al.
Publicado: (2016)

DNA repair byproduct 8-oxoguanine base promotes myoblast differentiation
por: Zheng, Xu, et al.
Publicado: (2023)

Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
por: Castillo, Erika, et al.
Publicado: (2017)

Author Correction: Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
por: Castillo, Erika, et al.
Publicado: (2021)

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer’s disease
por: Oka, Sugako, et al.
Publicado: (2016)

Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson's Disease
por: Fujita, Kyota, et al.
Publicado: (2009)

A high‐fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the App (NL−F/NL−F) knock‐in mouse model
por: Mazzei, Guianfranco, et al.
Publicado: (2021)

Neural stem cell–specific ITPA deficiency causes neural depolarization and epilepsy
por: Koga, Yuichiro, et al.
Publicado: (2020)

Abnormality in Wnt Signaling is Causatively Associated with Oxidative Stress-Induced Intestinal Tumorigenesis in MUTYH-Null Mice
por: Isoda, Takuro, et al.
Publicado: (2014)

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin-Induced Cardiac Dysfunction
por: Anene-Nzelu, Chukwuemeka George, et al.
Publicado: (2022)

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells
por: Yoneshima, Yasuto, et al.
Publicado: (2016)

Mismatch Repair Deficient Mice Show Susceptibility to Oxidative Stress-Induced Intestinal Carcinogenesis
por: Piao, Jingshu, et al.
Publicado: (2013)

Thermodynamic and kinetic basis for recognition and repair of 8-oxoguanine in DNA by human 8-oxoguanine-DNA glycosylase
por: Kirpota, Oleg O., et al.
Publicado: (2011)

Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression
por: Oka, Sugako, et al.
Publicado: (2022)

MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease
por: Mizuno, Yuri, et al.
Publicado: (2021)

Corrigendum to “MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease”
por: Mizuno, Yuri, et al.
Publicado: (2023)

Human cell-dependent, directional, time-dependent changes in the mono- and oligonucleotide compositions of SARS-CoV-2 genomes
por: Iwasaki, Yuki, et al.
Publicado: (2021)

Oligonucleotide usage in coronavirus genomes mimics that in exon regions in host genomes
por: Iwasaki, Yuki, et al.
Publicado: (2023)

Characterization of DNA with an 8-oxoguanine modification
por: Singh, Sreelekha K., et al.
Publicado: (2011)

Celecoxib and 2,5‐dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β‐catenin signaling pathway
por: Egashira, Issei, et al.
Publicado: (2016)

Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice
por: Arime, Yosefu, et al.
Publicado: (2014)

Epigenetic control of type III interferon expression by 8-oxoguanine and its reader 8-oxoguanine DNA glycosylase1
por: Xue, Yaoyao, et al.
Publicado: (2023)

Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice
por: Aoki, Yasunobu, et al.
Publicado: (2021)

Regulation of GC box activity by 8-oxoguanine
por: Müller, Nadine, et al.
Publicado: (2021)

Lost in the Crowd: How Does Human 8-Oxoguanine DNA Glycosylase 1 (OGG1) Find 8-Oxoguanine in the Genome?
por: D’Augustin, Ostiane, et al.
Publicado: (2020)

Implication of a new function of human tDNAs in chromatin organization
por: Iwasaki, Yuki, et al.
Publicado: (2020)

A Comprehensive Mouse Transcriptomic BodyMap across 17 Tissues by RNA-seq
por: Li, Bin, et al.
Publicado: (2017)

8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury
por: Pan, Lang, et al.
Publicado: (2023)

Transcriptional Mutagenesis Induced by 8-Oxoguanine in Mammalian Cells
por: Brégeon, Damien, et al.
Publicado: (2009)

The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation
por: Ba, Xueqing, et al.
Publicado: (2014)

Circadian Modulation of 8-Oxoguanine DNA Damage Repair
por: Manzella, Nicola, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_3v8kt18q0nkdvv70sd3puptmd1