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Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer

Approximately 90% of non-medullary thyroid malignancies originate from the follicular cell and are classified as papillary or follicular (well-differentiated) thyroid carcinomas, showing an overall favourable prognosis. However, recurrence or persistence of the disease occurs in some cases associate...

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Autores principales: Andrade, Bruno Moulin, de Carvalho, Denise Pires
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986867/
https://www.ncbi.nlm.nih.gov/pubmed/27919039
http://dx.doi.org/10.1042/BSR20130134
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author Andrade, Bruno Moulin
de Carvalho, Denise Pires
author_facet Andrade, Bruno Moulin
de Carvalho, Denise Pires
author_sort Andrade, Bruno Moulin
collection PubMed
description Approximately 90% of non-medullary thyroid malignancies originate from the follicular cell and are classified as papillary or follicular (well-differentiated) thyroid carcinomas, showing an overall favourable prognosis. However, recurrence or persistence of the disease occurs in some cases associated with the presence of loco-regional or distant metastatic lesions that generally become resistant to radioiodine therapy, while glucose uptake and metabolism are increased. Recent advances in the field of tumor progression have shown that CTC (circulating tumour cells) are metabolic and genetically heterogeneous. There is now special interest in unravelling the mechanisms that allow the reminiscence of dormant tumour lesions that might be related to late disease progression and increased risk of recurrence. AMPK (AMP-activated protein kinase) is activated by the depletion in cellular energy levels and allows adaptive changes in cell metabolism that are fundamental for cell survival in a stressful environment; nevertheless, the activation of this kinase also decreases cell proliferation rate and induces tumour cell apoptosis. In the thyroid field, AMPK emerged as a novel important intracellular pathway, since it regulates both iodide and glucose uptakes in normal thyroid cells. Furthermore, it has recently been demonstrated that the AMPK pathway is highly activated in papillary thyroid carcinomas, although the clinical significance of these findings remains elusive. Herein we review the current knowledge about the role of AMPK activation in thyroid physiology and pathophysiology, with special focus on thyroid cancer.
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spelling pubmed-39868672014-04-16 Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer Andrade, Bruno Moulin de Carvalho, Denise Pires Biosci Rep Review Article Approximately 90% of non-medullary thyroid malignancies originate from the follicular cell and are classified as papillary or follicular (well-differentiated) thyroid carcinomas, showing an overall favourable prognosis. However, recurrence or persistence of the disease occurs in some cases associated with the presence of loco-regional or distant metastatic lesions that generally become resistant to radioiodine therapy, while glucose uptake and metabolism are increased. Recent advances in the field of tumor progression have shown that CTC (circulating tumour cells) are metabolic and genetically heterogeneous. There is now special interest in unravelling the mechanisms that allow the reminiscence of dormant tumour lesions that might be related to late disease progression and increased risk of recurrence. AMPK (AMP-activated protein kinase) is activated by the depletion in cellular energy levels and allows adaptive changes in cell metabolism that are fundamental for cell survival in a stressful environment; nevertheless, the activation of this kinase also decreases cell proliferation rate and induces tumour cell apoptosis. In the thyroid field, AMPK emerged as a novel important intracellular pathway, since it regulates both iodide and glucose uptakes in normal thyroid cells. Furthermore, it has recently been demonstrated that the AMPK pathway is highly activated in papillary thyroid carcinomas, although the clinical significance of these findings remains elusive. Herein we review the current knowledge about the role of AMPK activation in thyroid physiology and pathophysiology, with special focus on thyroid cancer. Portland Press Ltd. 2014-04-15 /pmc/articles/PMC3986867/ /pubmed/27919039 http://dx.doi.org/10.1042/BSR20130134 Text en © 2014 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Andrade, Bruno Moulin
de Carvalho, Denise Pires
Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer
title Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer
title_full Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer
title_fullStr Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer
title_full_unstemmed Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer
title_short Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer
title_sort perspectives of the amp-activated kinase (ampk) signalling pathway in thyroid cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986867/
https://www.ncbi.nlm.nih.gov/pubmed/27919039
http://dx.doi.org/10.1042/BSR20130134
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