Cargando…
Intravenous ferric carboxymaltose for anaemia in pregnancy
BACKGROUND: Iron deficiency is a common nutritional deficiency amongst women of childbearing age. Peri-partum iron deficiency anaemia (IDA) is associated with significant maternal, fetal and infant morbidity. Current options for treatment are limited: these include oral iron supplementation, which c...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986933/ https://www.ncbi.nlm.nih.gov/pubmed/24667031 http://dx.doi.org/10.1186/1471-2393-14-115 |
_version_ | 1782311794679742464 |
---|---|
author | Froessler, Bernd Collingwood, Joshua Hodyl, Nicolette A Dekker, Gustaaf |
author_facet | Froessler, Bernd Collingwood, Joshua Hodyl, Nicolette A Dekker, Gustaaf |
author_sort | Froessler, Bernd |
collection | PubMed |
description | BACKGROUND: Iron deficiency is a common nutritional deficiency amongst women of childbearing age. Peri-partum iron deficiency anaemia (IDA) is associated with significant maternal, fetal and infant morbidity. Current options for treatment are limited: these include oral iron supplementation, which can be ineffective and poorly tolerated, and red blood cell transfusions, which carry an inherent risk and should be avoided. Ferric carboxymaltose is a new treatment option that may be better tolerated. The study was designed to assess the safety and efficacy of iron deficiency anaemia (IDA) correction with intravenous ferric carboxymaltose in pregnant women with mild, moderate and severe anaemia in the second and third trimester. METHODS: Prospective observational study; 65 anaemic pregnant women received ferric carboxymaltose up to 15 mg/kg between 24 and 40 weeks of pregnancy (median 35 weeks gestational age, SD 3.6). Treatment effectiveness was assessed by repeat haemoglobin (Hb) measurements and patient report of well-being in the postpartum period. Safety was assessed by analysis of adverse drug reactions and fetal heart rate monitoring during the infusion. RESULTS: Intravenous ferric carboxymaltose infusion significantly increased Hb values (p < 0.01) above baseline levels in all women. Increased Hb values were observed at 3 and 6 weeks post infusion and up to 8 weeks post-infusion. Ferritin values increased significantly after the infusion. Only 4 women had repeat ferritin values post-partum which remained above baseline levels. Fetal heart rate monitoring did not indicate a drug related negative impact on the fetus. Of the 29 (44.6%) women interviewed, 19 (65.5%) women reported an improvement in their well-being and 9 (31%) felt no different after the infusion. None of the women felt worse. No serious adverse effects were found and minor side effects occurred in 13 (20%) patients. CONCLUSIONS: Our prospective data is consistent with existing observational reports of the safe and effective use of ferric carboxymaltose in the treatment of iron deficiency anaemia in pregnancy. |
format | Online Article Text |
id | pubmed-3986933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39869332014-04-16 Intravenous ferric carboxymaltose for anaemia in pregnancy Froessler, Bernd Collingwood, Joshua Hodyl, Nicolette A Dekker, Gustaaf BMC Pregnancy Childbirth Research Article BACKGROUND: Iron deficiency is a common nutritional deficiency amongst women of childbearing age. Peri-partum iron deficiency anaemia (IDA) is associated with significant maternal, fetal and infant morbidity. Current options for treatment are limited: these include oral iron supplementation, which can be ineffective and poorly tolerated, and red blood cell transfusions, which carry an inherent risk and should be avoided. Ferric carboxymaltose is a new treatment option that may be better tolerated. The study was designed to assess the safety and efficacy of iron deficiency anaemia (IDA) correction with intravenous ferric carboxymaltose in pregnant women with mild, moderate and severe anaemia in the second and third trimester. METHODS: Prospective observational study; 65 anaemic pregnant women received ferric carboxymaltose up to 15 mg/kg between 24 and 40 weeks of pregnancy (median 35 weeks gestational age, SD 3.6). Treatment effectiveness was assessed by repeat haemoglobin (Hb) measurements and patient report of well-being in the postpartum period. Safety was assessed by analysis of adverse drug reactions and fetal heart rate monitoring during the infusion. RESULTS: Intravenous ferric carboxymaltose infusion significantly increased Hb values (p < 0.01) above baseline levels in all women. Increased Hb values were observed at 3 and 6 weeks post infusion and up to 8 weeks post-infusion. Ferritin values increased significantly after the infusion. Only 4 women had repeat ferritin values post-partum which remained above baseline levels. Fetal heart rate monitoring did not indicate a drug related negative impact on the fetus. Of the 29 (44.6%) women interviewed, 19 (65.5%) women reported an improvement in their well-being and 9 (31%) felt no different after the infusion. None of the women felt worse. No serious adverse effects were found and minor side effects occurred in 13 (20%) patients. CONCLUSIONS: Our prospective data is consistent with existing observational reports of the safe and effective use of ferric carboxymaltose in the treatment of iron deficiency anaemia in pregnancy. BioMed Central 2014-03-25 /pmc/articles/PMC3986933/ /pubmed/24667031 http://dx.doi.org/10.1186/1471-2393-14-115 Text en Copyright © 2014 Froessler et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Froessler, Bernd Collingwood, Joshua Hodyl, Nicolette A Dekker, Gustaaf Intravenous ferric carboxymaltose for anaemia in pregnancy |
title | Intravenous ferric carboxymaltose for anaemia in pregnancy |
title_full | Intravenous ferric carboxymaltose for anaemia in pregnancy |
title_fullStr | Intravenous ferric carboxymaltose for anaemia in pregnancy |
title_full_unstemmed | Intravenous ferric carboxymaltose for anaemia in pregnancy |
title_short | Intravenous ferric carboxymaltose for anaemia in pregnancy |
title_sort | intravenous ferric carboxymaltose for anaemia in pregnancy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986933/ https://www.ncbi.nlm.nih.gov/pubmed/24667031 http://dx.doi.org/10.1186/1471-2393-14-115 |
work_keys_str_mv | AT froesslerbernd intravenousferriccarboxymaltoseforanaemiainpregnancy AT collingwoodjoshua intravenousferriccarboxymaltoseforanaemiainpregnancy AT hodylnicolettea intravenousferriccarboxymaltoseforanaemiainpregnancy AT dekkergustaaf intravenousferriccarboxymaltoseforanaemiainpregnancy |