A new life for an old pump: V-ATPase and neurotransmitter release

Neurons fire by releasing neurotransmitters via fusion of synaptic vesicles with the plasma membrane. Fusion can be evoked by an incoming signal from a preceding neuron or can occur spontaneously. Synaptic vesicle fusion requires the formation of trans complexes between SNAREs as well as Ca(2+) ions...

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Detalles Bibliográficos
Autores principales: Vavassori, Stefano, Mayer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987142/
https://www.ncbi.nlm.nih.gov/pubmed/24733582
http://dx.doi.org/10.1083/jcb.201403040
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author Vavassori, Stefano
Mayer, Andreas
author_facet Vavassori, Stefano
Mayer, Andreas
author_sort Vavassori, Stefano
collection PubMed
description Neurons fire by releasing neurotransmitters via fusion of synaptic vesicles with the plasma membrane. Fusion can be evoked by an incoming signal from a preceding neuron or can occur spontaneously. Synaptic vesicle fusion requires the formation of trans complexes between SNAREs as well as Ca(2+) ions. Wang et al. (2014. J. Cell Biol. http://dx.doi.org/jcb.201312109) now find that the Ca(2+)-binding protein Calmodulin promotes spontaneous release and SNARE complex formation via its interaction with the V(0) sector of the V-ATPase.
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spelling pubmed-39871422014-10-14 A new life for an old pump: V-ATPase and neurotransmitter release Vavassori, Stefano Mayer, Andreas J Cell Biol Reviews Neurons fire by releasing neurotransmitters via fusion of synaptic vesicles with the plasma membrane. Fusion can be evoked by an incoming signal from a preceding neuron or can occur spontaneously. Synaptic vesicle fusion requires the formation of trans complexes between SNAREs as well as Ca(2+) ions. Wang et al. (2014. J. Cell Biol. http://dx.doi.org/jcb.201312109) now find that the Ca(2+)-binding protein Calmodulin promotes spontaneous release and SNARE complex formation via its interaction with the V(0) sector of the V-ATPase. The Rockefeller University Press 2014-04-14 /pmc/articles/PMC3987142/ /pubmed/24733582 http://dx.doi.org/10.1083/jcb.201403040 Text en © 2014 Vavassori and Mayer This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Vavassori, Stefano
Mayer, Andreas
A new life for an old pump: V-ATPase and neurotransmitter release
title A new life for an old pump: V-ATPase and neurotransmitter release
title_full A new life for an old pump: V-ATPase and neurotransmitter release
title_fullStr A new life for an old pump: V-ATPase and neurotransmitter release
title_full_unstemmed A new life for an old pump: V-ATPase and neurotransmitter release
title_short A new life for an old pump: V-ATPase and neurotransmitter release
title_sort new life for an old pump: v-atpase and neurotransmitter release
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987142/
https://www.ncbi.nlm.nih.gov/pubmed/24733582
http://dx.doi.org/10.1083/jcb.201403040
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