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Circulating adiponectin levels in Indian patients with psoriasis and its relation to metabolic syndrome

BACKGROUND: Adiponectin is a cytokine mainly secreted from the adipose tissue, which has insulin-sensitizing effects, antiatherosclerotic actions, and antiinflammatory properties. There are a few studies that have demonstrated that adiponectin is reduced in patients with psoriasis suggesting that th...

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Autores principales: Madanagobalane, Shraddha, Sandhya, Venkatswami, Anandan, Sankarasubramanian, Seshadri, Krishna G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987269/
https://www.ncbi.nlm.nih.gov/pubmed/24741515
http://dx.doi.org/10.4103/2230-8210.129110
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author Madanagobalane, Shraddha
Sandhya, Venkatswami
Anandan, Sankarasubramanian
Seshadri, Krishna G.
author_facet Madanagobalane, Shraddha
Sandhya, Venkatswami
Anandan, Sankarasubramanian
Seshadri, Krishna G.
author_sort Madanagobalane, Shraddha
collection PubMed
description BACKGROUND: Adiponectin is a cytokine mainly secreted from the adipose tissue, which has insulin-sensitizing effects, antiatherosclerotic actions, and antiinflammatory properties. There are a few studies that have demonstrated that adiponectin is reduced in patients with psoriasis suggesting that this adipocytokine may have a role in the pathogenesis of psoriasis. There have been no studies so far on adiponectin in relation to psoriasis and metabolic syndrome (MetS). OBJECTIVES: This study was performed to analyze serum adiponectin and insulin levels in psoriasis patients with and without MetS and in controls with and without MetS. MATERIALS AND METHODS: We performed a case control study on 60 psoriasis patients, 29 with MetS and 31 without MetS and 40 controls, 20 with and 20 without MetS, matched for age, sex, and body mass index (BMI). Fasting serum insulin and adiponectin levels were measured in all groups. RESULTS: The overall serum adiponectin levels were significantly reduced in psoriasis patients when compared with controls (P = 0.000). A significant reduction was also observed in psoriasis patients with MetS than those without MetS in the same group (P = 0.000). Similar decrease was observed between those with MetS in the psoriasis and control groups (P = 0.001). The lowest mean value of serum adiponectin (6387.9 ng/ml) was observed in psoriasis with MetS group and highest value (12146.3 ng/ml) in controls without MetS. CONCLUSION: Adiponectin levels are decreased in psoriasis patients irrespective of MetS thus indicating a role in its pathogenesis. This study prompts future trials on drugs increasing adiponectin levels in patients with psoriasis.
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spelling pubmed-39872692014-04-16 Circulating adiponectin levels in Indian patients with psoriasis and its relation to metabolic syndrome Madanagobalane, Shraddha Sandhya, Venkatswami Anandan, Sankarasubramanian Seshadri, Krishna G. Indian J Endocrinol Metab Original Article BACKGROUND: Adiponectin is a cytokine mainly secreted from the adipose tissue, which has insulin-sensitizing effects, antiatherosclerotic actions, and antiinflammatory properties. There are a few studies that have demonstrated that adiponectin is reduced in patients with psoriasis suggesting that this adipocytokine may have a role in the pathogenesis of psoriasis. There have been no studies so far on adiponectin in relation to psoriasis and metabolic syndrome (MetS). OBJECTIVES: This study was performed to analyze serum adiponectin and insulin levels in psoriasis patients with and without MetS and in controls with and without MetS. MATERIALS AND METHODS: We performed a case control study on 60 psoriasis patients, 29 with MetS and 31 without MetS and 40 controls, 20 with and 20 without MetS, matched for age, sex, and body mass index (BMI). Fasting serum insulin and adiponectin levels were measured in all groups. RESULTS: The overall serum adiponectin levels were significantly reduced in psoriasis patients when compared with controls (P = 0.000). A significant reduction was also observed in psoriasis patients with MetS than those without MetS in the same group (P = 0.000). Similar decrease was observed between those with MetS in the psoriasis and control groups (P = 0.001). The lowest mean value of serum adiponectin (6387.9 ng/ml) was observed in psoriasis with MetS group and highest value (12146.3 ng/ml) in controls without MetS. CONCLUSION: Adiponectin levels are decreased in psoriasis patients irrespective of MetS thus indicating a role in its pathogenesis. This study prompts future trials on drugs increasing adiponectin levels in patients with psoriasis. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC3987269/ /pubmed/24741515 http://dx.doi.org/10.4103/2230-8210.129110 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Madanagobalane, Shraddha
Sandhya, Venkatswami
Anandan, Sankarasubramanian
Seshadri, Krishna G.
Circulating adiponectin levels in Indian patients with psoriasis and its relation to metabolic syndrome
title Circulating adiponectin levels in Indian patients with psoriasis and its relation to metabolic syndrome
title_full Circulating adiponectin levels in Indian patients with psoriasis and its relation to metabolic syndrome
title_fullStr Circulating adiponectin levels in Indian patients with psoriasis and its relation to metabolic syndrome
title_full_unstemmed Circulating adiponectin levels in Indian patients with psoriasis and its relation to metabolic syndrome
title_short Circulating adiponectin levels in Indian patients with psoriasis and its relation to metabolic syndrome
title_sort circulating adiponectin levels in indian patients with psoriasis and its relation to metabolic syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987269/
https://www.ncbi.nlm.nih.gov/pubmed/24741515
http://dx.doi.org/10.4103/2230-8210.129110
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