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The Relationship between QT Interval Dispersion and End-Stage Liver Disease Score in the Patients Undergoing Orthotopic Liver Transplantation
BACKGROUND: This study was performed to determine the changes in corrected QT (QTc) and QT dispersion and their relationship with end-stage liver disease score in the children undergoing orthotopic liver transplantation. METHODS: This case-control study was performed in a 2–year period from February...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Safnek
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987450/ https://www.ncbi.nlm.nih.gov/pubmed/24757638 |
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author | Zahmatkeshan, Moghgan Fallahzadeh, Ebrahim Najib, Seyedeh Sadat Amoozgar, Hamid Malekhosseini, Seyed Ali Nikeghbalian, Saman |
author_facet | Zahmatkeshan, Moghgan Fallahzadeh, Ebrahim Najib, Seyedeh Sadat Amoozgar, Hamid Malekhosseini, Seyed Ali Nikeghbalian, Saman |
author_sort | Zahmatkeshan, Moghgan |
collection | PubMed |
description | BACKGROUND: This study was performed to determine the changes in corrected QT (QTc) and QT dispersion and their relationship with end-stage liver disease score in the children undergoing orthotopic liver transplantation. METHODS: This case-control study was performed in a 2–year period from February 2009 to March 2011 in Department of Organ Transplantation of Nemazee Hospital. We consecutively included all the 22 pediatric patients undergoing orthotopic liver transplantation and 22 healthy age- and sex-matched controls. Electrocardiogram (ECG) was performed for all the patients and controls before and 6 months after the transplantation and the QTc was calculated according to Bazett’s formula in lead I, aVF, andV1. Besides, QT dispersion was calculated by the difference between maximum and minimum QTc in the three leads. The data were statistically analyzed using independent sample t-test, chi-square test, paired t-test, and Pearson correlation analysis. In addition, P value < 0.05 was considered as statistically significant. RESULTS: The patients with end-stage liver disease had significantly longer QTc dispersion (P = 0.002) compared to the controls. The post-transplantation QTc dispersion (P = 0.003) was also significantly longer compared to the healthy controls. Moreover, pretransplant QTc dispersion was negatively correlated with weight (r = ‒0.589, P = 0.004) and Child-Pugh score (r = ‒0.549, P = 0.008). CONCLUSIONS: The patients with ESLD awaiting liver transplantation suffer from prolonged QTc interval predisposing them to ventricular tachycardia. The QTc prolongation in these patients does not response to liver transplantation. This study revealed a fine negative correlation between the Child- Pugh score and QTc. |
format | Online Article Text |
id | pubmed-3987450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Safnek |
record_format | MEDLINE/PubMed |
spelling | pubmed-39874502014-04-22 The Relationship between QT Interval Dispersion and End-Stage Liver Disease Score in the Patients Undergoing Orthotopic Liver Transplantation Zahmatkeshan, Moghgan Fallahzadeh, Ebrahim Najib, Seyedeh Sadat Amoozgar, Hamid Malekhosseini, Seyed Ali Nikeghbalian, Saman Int Cardiovasc Res J Research Article BACKGROUND: This study was performed to determine the changes in corrected QT (QTc) and QT dispersion and their relationship with end-stage liver disease score in the children undergoing orthotopic liver transplantation. METHODS: This case-control study was performed in a 2–year period from February 2009 to March 2011 in Department of Organ Transplantation of Nemazee Hospital. We consecutively included all the 22 pediatric patients undergoing orthotopic liver transplantation and 22 healthy age- and sex-matched controls. Electrocardiogram (ECG) was performed for all the patients and controls before and 6 months after the transplantation and the QTc was calculated according to Bazett’s formula in lead I, aVF, andV1. Besides, QT dispersion was calculated by the difference between maximum and minimum QTc in the three leads. The data were statistically analyzed using independent sample t-test, chi-square test, paired t-test, and Pearson correlation analysis. In addition, P value < 0.05 was considered as statistically significant. RESULTS: The patients with end-stage liver disease had significantly longer QTc dispersion (P = 0.002) compared to the controls. The post-transplantation QTc dispersion (P = 0.003) was also significantly longer compared to the healthy controls. Moreover, pretransplant QTc dispersion was negatively correlated with weight (r = ‒0.589, P = 0.004) and Child-Pugh score (r = ‒0.549, P = 0.008). CONCLUSIONS: The patients with ESLD awaiting liver transplantation suffer from prolonged QTc interval predisposing them to ventricular tachycardia. The QTc prolongation in these patients does not response to liver transplantation. This study revealed a fine negative correlation between the Child- Pugh score and QTc. Safnek 2013-12-01 2013-12 /pmc/articles/PMC3987450/ /pubmed/24757638 Text en Copyright © 2013, International Cardivascular Research Journal. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zahmatkeshan, Moghgan Fallahzadeh, Ebrahim Najib, Seyedeh Sadat Amoozgar, Hamid Malekhosseini, Seyed Ali Nikeghbalian, Saman The Relationship between QT Interval Dispersion and End-Stage Liver Disease Score in the Patients Undergoing Orthotopic Liver Transplantation |
title | The Relationship between QT Interval Dispersion and End-Stage Liver Disease Score in the Patients Undergoing Orthotopic Liver Transplantation |
title_full | The Relationship between QT Interval Dispersion and End-Stage Liver Disease Score in the Patients Undergoing Orthotopic Liver Transplantation |
title_fullStr | The Relationship between QT Interval Dispersion and End-Stage Liver Disease Score in the Patients Undergoing Orthotopic Liver Transplantation |
title_full_unstemmed | The Relationship between QT Interval Dispersion and End-Stage Liver Disease Score in the Patients Undergoing Orthotopic Liver Transplantation |
title_short | The Relationship between QT Interval Dispersion and End-Stage Liver Disease Score in the Patients Undergoing Orthotopic Liver Transplantation |
title_sort | relationship between qt interval dispersion and end-stage liver disease score in the patients undergoing orthotopic liver transplantation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987450/ https://www.ncbi.nlm.nih.gov/pubmed/24757638 |
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