JAK inhibitors suppress t(8;21) fusion protein-induced leukemia

Oncogenic mutations in components of the JAK/STAT pathway, including those in cytokine receptors and JAKs, lead to increased activity of downstream signaling and are frequently found in leukemia and other hematological disorders. Thus, small-molecule inhibitors of this pathway have been the focus of...

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Detalles Bibliográficos
Autores principales: Lo, Miao-Chia, Peterson, Luke F., Yan, Ming, Cong, Xiuli, Hickman, Justin H., DeKelver, Russel C., Niewerth, Denise, Zhang, Dong-Er
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987672/
https://www.ncbi.nlm.nih.gov/pubmed/23812420
http://dx.doi.org/10.1038/leu.2013.197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987672/
https://www.ncbi.nlm.nih.gov/pubmed/23812420
http://dx.doi.org/10.1038/leu.2013.197

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