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Morbidity due to acute lower respiratory infection in children with birth defects: a total population-based linked data study

BACKGROUND: Acute lower respiratory infections (ALRIs) are leading causes of hospitalisation in children. Birth defects occur in 5% of live births in Western Australia (WA). The association between birth defects and ALRI hospitalisation is unknown. METHODS: We conducted a retrospective cohort study...

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Autores principales: Jama-Alol, Khadra A, Moore, Hannah C, Jacoby, Peter, Bower, Carol, Lehmann, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987821/
https://www.ncbi.nlm.nih.gov/pubmed/24661413
http://dx.doi.org/10.1186/1471-2431-14-80
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author Jama-Alol, Khadra A
Moore, Hannah C
Jacoby, Peter
Bower, Carol
Lehmann, Deborah
author_facet Jama-Alol, Khadra A
Moore, Hannah C
Jacoby, Peter
Bower, Carol
Lehmann, Deborah
author_sort Jama-Alol, Khadra A
collection PubMed
description BACKGROUND: Acute lower respiratory infections (ALRIs) are leading causes of hospitalisation in children. Birth defects occur in 5% of live births in Western Australia (WA). The association between birth defects and ALRI hospitalisation is unknown. METHODS: We conducted a retrospective cohort study of 245,249 singleton births in WA (1996-2005). Population-based hospitalisation data were linked to the WA Register of Developmental Anomalies to investigate ALRI hospitalisations in children with and without birth defects. We used negative binomial regression to estimate associations between birth defects and number of ALRI hospitalisations before age 2 years, adjusting for known risk factors. RESULTS: Overall, 9% of non-Aboriginal children and 37% of Aboriginal children with birth defects had at least one ALRI admission before age 2 years. Aboriginal children (IRR 2.3, 95% CI: 1.9-2.8) and non-Aboriginal children (IRR 2.0, 95% CI: 1.8-2.2) with birth defects had higher rates of hospitalisation for an ALRI than children with no birth defects. Rates of ALRI hospitalisation varied by type of defect but were increased for all major birth defects categories, the highest rate being for children with Down syndrome (IRR 8.0, 95% CI: 5.6-11.5). The rate of ALRI hospitalisation was 3 times greater in children with multiple birth defects than in those with isolated defects. CONCLUSIONS: Children with birth defects experience higher rates of hospitalisation for ALRIs before age 2 years than children with no birth defects. Optimal vaccination coverage and immunoprophylaxis for specific categories of birth defects would assist in reducing hospitalisation rates for ALRI.
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spelling pubmed-39878212014-04-16 Morbidity due to acute lower respiratory infection in children with birth defects: a total population-based linked data study Jama-Alol, Khadra A Moore, Hannah C Jacoby, Peter Bower, Carol Lehmann, Deborah BMC Pediatr Research Article BACKGROUND: Acute lower respiratory infections (ALRIs) are leading causes of hospitalisation in children. Birth defects occur in 5% of live births in Western Australia (WA). The association between birth defects and ALRI hospitalisation is unknown. METHODS: We conducted a retrospective cohort study of 245,249 singleton births in WA (1996-2005). Population-based hospitalisation data were linked to the WA Register of Developmental Anomalies to investigate ALRI hospitalisations in children with and without birth defects. We used negative binomial regression to estimate associations between birth defects and number of ALRI hospitalisations before age 2 years, adjusting for known risk factors. RESULTS: Overall, 9% of non-Aboriginal children and 37% of Aboriginal children with birth defects had at least one ALRI admission before age 2 years. Aboriginal children (IRR 2.3, 95% CI: 1.9-2.8) and non-Aboriginal children (IRR 2.0, 95% CI: 1.8-2.2) with birth defects had higher rates of hospitalisation for an ALRI than children with no birth defects. Rates of ALRI hospitalisation varied by type of defect but were increased for all major birth defects categories, the highest rate being for children with Down syndrome (IRR 8.0, 95% CI: 5.6-11.5). The rate of ALRI hospitalisation was 3 times greater in children with multiple birth defects than in those with isolated defects. CONCLUSIONS: Children with birth defects experience higher rates of hospitalisation for ALRIs before age 2 years than children with no birth defects. Optimal vaccination coverage and immunoprophylaxis for specific categories of birth defects would assist in reducing hospitalisation rates for ALRI. BioMed Central 2014-03-25 /pmc/articles/PMC3987821/ /pubmed/24661413 http://dx.doi.org/10.1186/1471-2431-14-80 Text en Copyright © 2014 Jama-Alol et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Jama-Alol, Khadra A
Moore, Hannah C
Jacoby, Peter
Bower, Carol
Lehmann, Deborah
Morbidity due to acute lower respiratory infection in children with birth defects: a total population-based linked data study
title Morbidity due to acute lower respiratory infection in children with birth defects: a total population-based linked data study
title_full Morbidity due to acute lower respiratory infection in children with birth defects: a total population-based linked data study
title_fullStr Morbidity due to acute lower respiratory infection in children with birth defects: a total population-based linked data study
title_full_unstemmed Morbidity due to acute lower respiratory infection in children with birth defects: a total population-based linked data study
title_short Morbidity due to acute lower respiratory infection in children with birth defects: a total population-based linked data study
title_sort morbidity due to acute lower respiratory infection in children with birth defects: a total population-based linked data study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987821/
https://www.ncbi.nlm.nih.gov/pubmed/24661413
http://dx.doi.org/10.1186/1471-2431-14-80
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