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Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease

The escalating epidemic of obesity has increased the incidence of obesity-induced complications to historically high levels. Adipose tissue is a dynamic energy depot, which stores energy and mobilizes it during nutrient deficiency. Excess nutrient intake resulting in adipose tissue expansion trigger...

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Autores principales: Yao, Longbiao, Herlea-Pana, Oana, Heuser-Baker, Janet, Chen, Yitong, Barlic-Dicen, Jana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987870/
https://www.ncbi.nlm.nih.gov/pubmed/24741577
http://dx.doi.org/10.1155/2014/181450
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author Yao, Longbiao
Herlea-Pana, Oana
Heuser-Baker, Janet
Chen, Yitong
Barlic-Dicen, Jana
author_facet Yao, Longbiao
Herlea-Pana, Oana
Heuser-Baker, Janet
Chen, Yitong
Barlic-Dicen, Jana
author_sort Yao, Longbiao
collection PubMed
description The escalating epidemic of obesity has increased the incidence of obesity-induced complications to historically high levels. Adipose tissue is a dynamic energy depot, which stores energy and mobilizes it during nutrient deficiency. Excess nutrient intake resulting in adipose tissue expansion triggers lipid release and aberrant adipokine, cytokine and chemokine production, and signaling that ultimately lead to adipose tissue inflammation, a hallmark of obesity. This low-grade chronic inflammation is thought to link obesity to insulin resistance and the associated comorbidities of metabolic syndrome such as dyslipidemia and hypertension, which increase risk of type 2 diabetes and cardiovascular disease. In this review, we focus on and discuss members of the chemokine system for which there is clear evidence of participation in the development of obesity and obesity-induced pathologies.
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spelling pubmed-39878702014-04-16 Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease Yao, Longbiao Herlea-Pana, Oana Heuser-Baker, Janet Chen, Yitong Barlic-Dicen, Jana J Immunol Res Review Article The escalating epidemic of obesity has increased the incidence of obesity-induced complications to historically high levels. Adipose tissue is a dynamic energy depot, which stores energy and mobilizes it during nutrient deficiency. Excess nutrient intake resulting in adipose tissue expansion triggers lipid release and aberrant adipokine, cytokine and chemokine production, and signaling that ultimately lead to adipose tissue inflammation, a hallmark of obesity. This low-grade chronic inflammation is thought to link obesity to insulin resistance and the associated comorbidities of metabolic syndrome such as dyslipidemia and hypertension, which increase risk of type 2 diabetes and cardiovascular disease. In this review, we focus on and discuss members of the chemokine system for which there is clear evidence of participation in the development of obesity and obesity-induced pathologies. Hindawi Publishing Corporation 2014 2014-03-16 /pmc/articles/PMC3987870/ /pubmed/24741577 http://dx.doi.org/10.1155/2014/181450 Text en Copyright © 2014 Longbiao Yao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yao, Longbiao
Herlea-Pana, Oana
Heuser-Baker, Janet
Chen, Yitong
Barlic-Dicen, Jana
Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease
title Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease
title_full Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease
title_fullStr Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease
title_full_unstemmed Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease
title_short Roles of the Chemokine System in Development of Obesity, Insulin Resistance, and Cardiovascular Disease
title_sort roles of the chemokine system in development of obesity, insulin resistance, and cardiovascular disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987870/
https://www.ncbi.nlm.nih.gov/pubmed/24741577
http://dx.doi.org/10.1155/2014/181450
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