Potential Benefits of Therapeutic Use of β2-Adrenergic Receptor Agonists in Neuroprotection and Parkinsonμs Disease

The β2-adrenergic receptor (β2AR) is a seven-transmembrane (7TM) G-protein coupled receptor that is expressed on cells of the pulmonary, cardiac, skeletal muscle, and immune systems. Previous work has shown that stimulation of this receptor on immune cells has profound effects on the regulatory acti...

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Detalles Bibliográficos
Autores principales: Peterson, Lynda, Ismond, Kathleen P., Chapman, Elisha, Flood, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987873/
https://www.ncbi.nlm.nih.gov/pubmed/24741572
http://dx.doi.org/10.1155/2014/103780
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author Peterson, Lynda
Ismond, Kathleen P.
Chapman, Elisha
Flood, Patrick
author_facet Peterson, Lynda
Ismond, Kathleen P.
Chapman, Elisha
Flood, Patrick
author_sort Peterson, Lynda
collection PubMed
description The β2-adrenergic receptor (β2AR) is a seven-transmembrane (7TM) G-protein coupled receptor that is expressed on cells of the pulmonary, cardiac, skeletal muscle, and immune systems. Previous work has shown that stimulation of this receptor on immune cells has profound effects on the regulatory activity of both adaptive and innate immune cells. This review examines the functional dichotomy associated with stimulation of β2AR and microglial cells. As well, recent studies targeting these receptors with long-acting agonists are considered with respect to their therapeutic potential in management of Parkinsonμs disease.
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spelling pubmed-39878732014-04-16 Potential Benefits of Therapeutic Use of β2-Adrenergic Receptor Agonists in Neuroprotection and Parkinsonμs Disease Peterson, Lynda Ismond, Kathleen P. Chapman, Elisha Flood, Patrick J Immunol Res Review Article The β2-adrenergic receptor (β2AR) is a seven-transmembrane (7TM) G-protein coupled receptor that is expressed on cells of the pulmonary, cardiac, skeletal muscle, and immune systems. Previous work has shown that stimulation of this receptor on immune cells has profound effects on the regulatory activity of both adaptive and innate immune cells. This review examines the functional dichotomy associated with stimulation of β2AR and microglial cells. As well, recent studies targeting these receptors with long-acting agonists are considered with respect to their therapeutic potential in management of Parkinsonμs disease. Hindawi Publishing Corporation 2014 2014-01-19 /pmc/articles/PMC3987873/ /pubmed/24741572 http://dx.doi.org/10.1155/2014/103780 Text en Copyright © 2014 Lynda Peterson et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Peterson, Lynda
Ismond, Kathleen P.
Chapman, Elisha
Flood, Patrick
Potential Benefits of Therapeutic Use of β2-Adrenergic Receptor Agonists in Neuroprotection and Parkinsonμs Disease
title Potential Benefits of Therapeutic Use of β2-Adrenergic Receptor Agonists in Neuroprotection and Parkinsonμs Disease
title_full Potential Benefits of Therapeutic Use of β2-Adrenergic Receptor Agonists in Neuroprotection and Parkinsonμs Disease
title_fullStr Potential Benefits of Therapeutic Use of β2-Adrenergic Receptor Agonists in Neuroprotection and Parkinsonμs Disease
title_full_unstemmed Potential Benefits of Therapeutic Use of β2-Adrenergic Receptor Agonists in Neuroprotection and Parkinsonμs Disease
title_short Potential Benefits of Therapeutic Use of β2-Adrenergic Receptor Agonists in Neuroprotection and Parkinsonμs Disease
title_sort potential benefits of therapeutic use of β2-adrenergic receptor agonists in neuroprotection and parkinsonμs disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987873/
https://www.ncbi.nlm.nih.gov/pubmed/24741572
http://dx.doi.org/10.1155/2014/103780
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