Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma

BACKGROUND: Medulloblastoma is the most common type of malignant brain tumor that afflicts children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients do poorly with significant morbidity. METHODS: To identify new molecular targets, we performed an int...

Descripción completa

Detalles Bibliográficos
Autores principales: Harris, Peter S, Venkataraman, Sujatha, Alimova, Irina, Birks, Diane K, Balakrishnan, Ilango, Cristiano, Brian, Donson, Andrew M, Dubuc, Adrian M, Taylor, Michael D, Foreman, Nicholas K, Reigan, Philip, Vibhakar, Rajeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987923/
https://www.ncbi.nlm.nih.gov/pubmed/24661910
http://dx.doi.org/10.1186/1476-4598-13-72

Ejemplares similares

Ejemplares similares