Cargando…
Insight into Gene Polymorphisms Involved in Toll-Like Receptor/Interferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia
Polymorphisms in genes involved in toll-like receptor/interferon signalling pathways have been reported previously to be associated with SLE in many populations. This study aimed to investigate the role of seven single nucleotide polymorphisms within TNFAIP3, STAT4, and IRF5, which are involved in u...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987947/ https://www.ncbi.nlm.nih.gov/pubmed/24741605 http://dx.doi.org/10.1155/2014/529167 |
_version_ | 1782311953059807232 |
---|---|
author | Chai, Hwa Chia Chua, Kek Heng Lim, Soo Kun Phipps, Maude Elvira |
author_facet | Chai, Hwa Chia Chua, Kek Heng Lim, Soo Kun Phipps, Maude Elvira |
author_sort | Chai, Hwa Chia |
collection | PubMed |
description | Polymorphisms in genes involved in toll-like receptor/interferon signalling pathways have been reported previously to be associated with SLE in many populations. This study aimed to investigate the role of seven single nucleotide polymorphisms within TNFAIP3, STAT4, and IRF5, which are involved in upstream and downstream pathways of type I interferon production, in SLE in the South East Asian populations. Genotyping of 360 Malaysian SLE patients and 430 normal healthy individuals revealed that minor alleles of STAT4 rs7574865 and rs10168266 were associated with elevated risk of SLE in the Chinese and Malay patients, respectively (P = 0.028, odds ratio (OR) = 1.42; P = 0.035, OR = 1.80, respectively). Polymorphisms in TNFAIP3 and IRF5 did not show significant associations with SLE in any of the ethnicities. Combined analysis of the Malays, Chinese, and Indians for each SNP indicated that STAT4 rs10168266 was significantly associated with the Malaysian SLE as a whole (P = 0.014; OR = 1.435). The meta-analysis of STAT4 rs10168266, which combined the data of other studies and this study, further confirmed its importance as the risk factor for SLE by having pooled OR of 1.559 and P value of <0.001. |
format | Online Article Text |
id | pubmed-3987947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39879472014-04-16 Insight into Gene Polymorphisms Involved in Toll-Like Receptor/Interferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia Chai, Hwa Chia Chua, Kek Heng Lim, Soo Kun Phipps, Maude Elvira J Immunol Res Research Article Polymorphisms in genes involved in toll-like receptor/interferon signalling pathways have been reported previously to be associated with SLE in many populations. This study aimed to investigate the role of seven single nucleotide polymorphisms within TNFAIP3, STAT4, and IRF5, which are involved in upstream and downstream pathways of type I interferon production, in SLE in the South East Asian populations. Genotyping of 360 Malaysian SLE patients and 430 normal healthy individuals revealed that minor alleles of STAT4 rs7574865 and rs10168266 were associated with elevated risk of SLE in the Chinese and Malay patients, respectively (P = 0.028, odds ratio (OR) = 1.42; P = 0.035, OR = 1.80, respectively). Polymorphisms in TNFAIP3 and IRF5 did not show significant associations with SLE in any of the ethnicities. Combined analysis of the Malays, Chinese, and Indians for each SNP indicated that STAT4 rs10168266 was significantly associated with the Malaysian SLE as a whole (P = 0.014; OR = 1.435). The meta-analysis of STAT4 rs10168266, which combined the data of other studies and this study, further confirmed its importance as the risk factor for SLE by having pooled OR of 1.559 and P value of <0.001. Hindawi Publishing Corporation 2014 2014-02-17 /pmc/articles/PMC3987947/ /pubmed/24741605 http://dx.doi.org/10.1155/2014/529167 Text en Copyright © 2014 Hwa Chia Chai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chai, Hwa Chia Chua, Kek Heng Lim, Soo Kun Phipps, Maude Elvira Insight into Gene Polymorphisms Involved in Toll-Like Receptor/Interferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia |
title | Insight into Gene Polymorphisms Involved in Toll-Like Receptor/Interferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia |
title_full | Insight into Gene Polymorphisms Involved in Toll-Like Receptor/Interferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia |
title_fullStr | Insight into Gene Polymorphisms Involved in Toll-Like Receptor/Interferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia |
title_full_unstemmed | Insight into Gene Polymorphisms Involved in Toll-Like Receptor/Interferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia |
title_short | Insight into Gene Polymorphisms Involved in Toll-Like Receptor/Interferon Signalling Pathways for Systemic Lupus Erythematosus in South East Asia |
title_sort | insight into gene polymorphisms involved in toll-like receptor/interferon signalling pathways for systemic lupus erythematosus in south east asia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987947/ https://www.ncbi.nlm.nih.gov/pubmed/24741605 http://dx.doi.org/10.1155/2014/529167 |
work_keys_str_mv | AT chaihwachia insightintogenepolymorphismsinvolvedintolllikereceptorinterferonsignallingpathwaysforsystemiclupuserythematosusinsoutheastasia AT chuakekheng insightintogenepolymorphismsinvolvedintolllikereceptorinterferonsignallingpathwaysforsystemiclupuserythematosusinsoutheastasia AT limsookun insightintogenepolymorphismsinvolvedintolllikereceptorinterferonsignallingpathwaysforsystemiclupuserythematosusinsoutheastasia AT phippsmaudeelvira insightintogenepolymorphismsinvolvedintolllikereceptorinterferonsignallingpathwaysforsystemiclupuserythematosusinsoutheastasia |