The Expression of Bcl-2 and BID in Gastric Cancer Cells

Background. Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence of Helicobacter pylori...

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Autores principales: Gryko, Mariusz, Pryczynicz, Anna, Zareba, Konrad, Kędra, Bogusław, Kemona, Andrzej, Guzińska-Ustymowicz, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987977/
https://www.ncbi.nlm.nih.gov/pubmed/24741635
http://dx.doi.org/10.1155/2014/953203
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author Gryko, Mariusz
Pryczynicz, Anna
Zareba, Konrad
Kędra, Bogusław
Kemona, Andrzej
Guzińska-Ustymowicz, Katarzyna
author_facet Gryko, Mariusz
Pryczynicz, Anna
Zareba, Konrad
Kędra, Bogusław
Kemona, Andrzej
Guzińska-Ustymowicz, Katarzyna
author_sort Gryko, Mariusz
collection PubMed
description Background. Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence of Helicobacter pylori infection, and patients' survival. Materials and Methods. The study involved 88 patients operated on for gastric cancer. The expressions of Bcl-2 and BID were determined immunohistochemically. Results. Positive Bcl-2 expression was found in 55.7% and, BID in 53.6% of patients. The Bcl-2 expression correlated with stage pT3 and T4 gastric cancer (P < 0.05), with the intestinal type according to Lauren (P < 0.001), ulcerated type according to Bormann's classification (P < 0.01), and with local lymph node metastases (P < 0.05). Conclusion. The Bcl-2 protein plays a key role in the process of gastric cancer formation and is associated with the growth of definite types of gastric cancer.
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spelling pubmed-39879772014-04-16 The Expression of Bcl-2 and BID in Gastric Cancer Cells Gryko, Mariusz Pryczynicz, Anna Zareba, Konrad Kędra, Bogusław Kemona, Andrzej Guzińska-Ustymowicz, Katarzyna J Immunol Res Clinical Study Background. Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence of Helicobacter pylori infection, and patients' survival. Materials and Methods. The study involved 88 patients operated on for gastric cancer. The expressions of Bcl-2 and BID were determined immunohistochemically. Results. Positive Bcl-2 expression was found in 55.7% and, BID in 53.6% of patients. The Bcl-2 expression correlated with stage pT3 and T4 gastric cancer (P < 0.05), with the intestinal type according to Lauren (P < 0.001), ulcerated type according to Bormann's classification (P < 0.01), and with local lymph node metastases (P < 0.05). Conclusion. The Bcl-2 protein plays a key role in the process of gastric cancer formation and is associated with the growth of definite types of gastric cancer. Hindawi Publishing Corporation 2014 2014-02-19 /pmc/articles/PMC3987977/ /pubmed/24741635 http://dx.doi.org/10.1155/2014/953203 Text en Copyright © 2014 Mariusz Gryko et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Gryko, Mariusz
Pryczynicz, Anna
Zareba, Konrad
Kędra, Bogusław
Kemona, Andrzej
Guzińska-Ustymowicz, Katarzyna
The Expression of Bcl-2 and BID in Gastric Cancer Cells
title The Expression of Bcl-2 and BID in Gastric Cancer Cells
title_full The Expression of Bcl-2 and BID in Gastric Cancer Cells
title_fullStr The Expression of Bcl-2 and BID in Gastric Cancer Cells
title_full_unstemmed The Expression of Bcl-2 and BID in Gastric Cancer Cells
title_short The Expression of Bcl-2 and BID in Gastric Cancer Cells
title_sort expression of bcl-2 and bid in gastric cancer cells
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987977/
https://www.ncbi.nlm.nih.gov/pubmed/24741635
http://dx.doi.org/10.1155/2014/953203
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