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Activation of GPER-1 Estradiol Receptor Downregulates Production of Testosterone in Isolated Rat Leydig Cells and Adult Human Testis
PURPOSE: Estradiol (E2) modulates testicular functions including steroidogenesis, but the mechanisms of E2 signaling in human testis are poorly understood. GPER-1 (GPR30), a G protein-coupled membrane receptor, mediates rapid genomic and non-genomic response to estrogens. The aim of this study was t...
Autores principales: | Vaucher, Laurent, Funaro, Michael G., Mehta, Akanksha, Mielnik, Anna, Bolyakov, Alexander, Prossnitz, Eric R., Schlegel, Peter N., Paduch, Darius A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987996/ https://www.ncbi.nlm.nih.gov/pubmed/24736568 http://dx.doi.org/10.1371/journal.pone.0092425 |
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