Fialuridine Induces Acute Liver Failure in Chimeric TK-NOG Mice: A Model for Detecting Hepatic Drug Toxicity Prior to Human Testing

BACKGROUND: Seven of 15 clinical trial participants treated with a nucleoside analogue (fialuridine [FIAU]) developed acute liver failure. Five treated participants died, and two required a liver transplant. Preclinical toxicology studies in mice, rats, dogs, and primates did not provide any indicat...

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Detalles Bibliográficos
Autores principales: Xu, Dan, Nishimura, Toshi, Nishimura, Sachiko, Zhang, Haili, Zheng, Ming, Guo, Ying-Ying, Masek, Marylin, Michie, Sara A., Glenn, Jeffrey, Peltz, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988005/
https://www.ncbi.nlm.nih.gov/pubmed/24736310
http://dx.doi.org/10.1371/journal.pmed.1001628

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