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The Contribution of Qualitative CEUS to the Determination of Malignancy in Adnexal Masses, Indeterminate on Conventional US – A Multicenter Study

The aim of this study is to evaluate the efficacy of qualitative analysis of contrast-enhanced ultrasound (CEUS) in discrimination of adnexal masses which were undetermined by conventional ultrasound (US). A total of 120 patients underwent transabdominal CEUS. The initial enhancement time and intens...

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Autores principales: Zhang, Xinling, Mao, Yongjiang, Zheng, Rongqin, Zheng, Zhijuan, Huang, Zeping, Huang, Dongmei, Zhang, Jing, Dai, Qing, Zhou, Xiaodong, Wen, Yanling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988034/
https://www.ncbi.nlm.nih.gov/pubmed/24736589
http://dx.doi.org/10.1371/journal.pone.0093843
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author Zhang, Xinling
Mao, Yongjiang
Zheng, Rongqin
Zheng, Zhijuan
Huang, Zeping
Huang, Dongmei
Zhang, Jing
Dai, Qing
Zhou, Xiaodong
Wen, Yanling
author_facet Zhang, Xinling
Mao, Yongjiang
Zheng, Rongqin
Zheng, Zhijuan
Huang, Zeping
Huang, Dongmei
Zhang, Jing
Dai, Qing
Zhou, Xiaodong
Wen, Yanling
author_sort Zhang, Xinling
collection PubMed
description The aim of this study is to evaluate the efficacy of qualitative analysis of contrast-enhanced ultrasound (CEUS) in discrimination of adnexal masses which were undetermined by conventional ultrasound (US). A total of 120 patients underwent transabdominal CEUS. The initial enhancement time and intensity compared with the uterine myometrium, contrast agent distribution patterns and dynamic changes of enhancement were assessed. The sensitivity (Sen), specificity (Spe), positive predictive value (PPV), negative predictive value (NPV), accuracy (ACC) and Youden’s index were calculated for contrast variables. The gold standard was the histological diagnosis. There were 48 malignant tumors and 72 benign tumors. The enhancement features of malignant masses were different from benign ones. Earlier or simultaneous enhancement with inhomogeneous enhancement yielded the highest capability in differential diagnosis, and Sen, Spe, PPV, NPV, ACC, Youden’s index was 89.6%, 97.2%, 93.2%, 95.6%, 93.3%, and 0.88, respectively. The qualitative evaluation of CEUS is useful in the differential diagnosis of adnexal masses where conventional US is indeterminate.
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spelling pubmed-39880342014-04-21 The Contribution of Qualitative CEUS to the Determination of Malignancy in Adnexal Masses, Indeterminate on Conventional US – A Multicenter Study Zhang, Xinling Mao, Yongjiang Zheng, Rongqin Zheng, Zhijuan Huang, Zeping Huang, Dongmei Zhang, Jing Dai, Qing Zhou, Xiaodong Wen, Yanling PLoS One Research Article The aim of this study is to evaluate the efficacy of qualitative analysis of contrast-enhanced ultrasound (CEUS) in discrimination of adnexal masses which were undetermined by conventional ultrasound (US). A total of 120 patients underwent transabdominal CEUS. The initial enhancement time and intensity compared with the uterine myometrium, contrast agent distribution patterns and dynamic changes of enhancement were assessed. The sensitivity (Sen), specificity (Spe), positive predictive value (PPV), negative predictive value (NPV), accuracy (ACC) and Youden’s index were calculated for contrast variables. The gold standard was the histological diagnosis. There were 48 malignant tumors and 72 benign tumors. The enhancement features of malignant masses were different from benign ones. Earlier or simultaneous enhancement with inhomogeneous enhancement yielded the highest capability in differential diagnosis, and Sen, Spe, PPV, NPV, ACC, Youden’s index was 89.6%, 97.2%, 93.2%, 95.6%, 93.3%, and 0.88, respectively. The qualitative evaluation of CEUS is useful in the differential diagnosis of adnexal masses where conventional US is indeterminate. Public Library of Science 2014-04-15 /pmc/articles/PMC3988034/ /pubmed/24736589 http://dx.doi.org/10.1371/journal.pone.0093843 Text en © 2014 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhang, Xinling
Mao, Yongjiang
Zheng, Rongqin
Zheng, Zhijuan
Huang, Zeping
Huang, Dongmei
Zhang, Jing
Dai, Qing
Zhou, Xiaodong
Wen, Yanling
The Contribution of Qualitative CEUS to the Determination of Malignancy in Adnexal Masses, Indeterminate on Conventional US – A Multicenter Study
title The Contribution of Qualitative CEUS to the Determination of Malignancy in Adnexal Masses, Indeterminate on Conventional US – A Multicenter Study
title_full The Contribution of Qualitative CEUS to the Determination of Malignancy in Adnexal Masses, Indeterminate on Conventional US – A Multicenter Study
title_fullStr The Contribution of Qualitative CEUS to the Determination of Malignancy in Adnexal Masses, Indeterminate on Conventional US – A Multicenter Study
title_full_unstemmed The Contribution of Qualitative CEUS to the Determination of Malignancy in Adnexal Masses, Indeterminate on Conventional US – A Multicenter Study
title_short The Contribution of Qualitative CEUS to the Determination of Malignancy in Adnexal Masses, Indeterminate on Conventional US – A Multicenter Study
title_sort contribution of qualitative ceus to the determination of malignancy in adnexal masses, indeterminate on conventional us – a multicenter study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988034/
https://www.ncbi.nlm.nih.gov/pubmed/24736589
http://dx.doi.org/10.1371/journal.pone.0093843
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