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Development and Validation of a Prediction Model for Tube Feeding Dependence after Curative (Chemo-) Radiation in Head and Neck Cancer

BACKGROUND: Curative radiotherapy or chemoradiation for head and neck cancer (HNC) may result in severe acute and late side effects, including tube feeding dependence. The purpose of this prospective cohort study was to develop a prediction model for tube feeding dependence 6 months (TUBE(M6)) after...

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Autores principales: Wopken, Kim, Bijl, Hendrik P., van der Schaaf, Arjen, Christianen, Miranda E., Chouvalova, Olga, Oosting, Sjoukje F., van der Laan, Bernard F. A. M., Roodenburg, Jan L. N., Leemans, C. René, Slotman, Ben J., Doornaert, Patricia, Steenbakkers, Roel J. H. M., Verdonck-de Leeuw, Irma M., Langendijk, Johannes A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988098/
https://www.ncbi.nlm.nih.gov/pubmed/24736318
http://dx.doi.org/10.1371/journal.pone.0094879
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author Wopken, Kim
Bijl, Hendrik P.
van der Schaaf, Arjen
Christianen, Miranda E.
Chouvalova, Olga
Oosting, Sjoukje F.
van der Laan, Bernard F. A. M.
Roodenburg, Jan L. N.
Leemans, C. René
Slotman, Ben J.
Doornaert, Patricia
Steenbakkers, Roel J. H. M.
Verdonck-de Leeuw, Irma M.
Langendijk, Johannes A.
author_facet Wopken, Kim
Bijl, Hendrik P.
van der Schaaf, Arjen
Christianen, Miranda E.
Chouvalova, Olga
Oosting, Sjoukje F.
van der Laan, Bernard F. A. M.
Roodenburg, Jan L. N.
Leemans, C. René
Slotman, Ben J.
Doornaert, Patricia
Steenbakkers, Roel J. H. M.
Verdonck-de Leeuw, Irma M.
Langendijk, Johannes A.
author_sort Wopken, Kim
collection PubMed
description BACKGROUND: Curative radiotherapy or chemoradiation for head and neck cancer (HNC) may result in severe acute and late side effects, including tube feeding dependence. The purpose of this prospective cohort study was to develop a prediction model for tube feeding dependence 6 months (TUBE(M6)) after curative (chemo-) radiotherapy in HNC patients. PATIENTS AND METHODS: Tube feeding dependence was scored prospectively. To develop the multivariable model, a group LASSO analysis was carried out, with TUBE(M6) as the primary endpoint (n = 427). The model was then validated in a test cohort (n = 183). The training cohort was divided into three groups based on the risk of TUBE(M6) to test whether the model could be extrapolated to later time points (12, 18 and 24 months). RESULTS: Most important predictors for TUBE(M6) were weight loss prior to treatment, advanced T-stage, positive N-stage, bilateral neck irradiation, accelerated radiotherapy and chemoradiation. Model performance was good, with an Area under the Curve of 0.86 in the training cohort and 0.82 in the test cohort. The TUBE(M6)-based risk groups were significantly associated with tube feeding dependence at later time points (p<0.001). CONCLUSION: We established an externally validated predictive model for tube feeding dependence after curative radiotherapy or chemoradiation, which can be used to predict TUBE(M6).
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spelling pubmed-39880982014-04-21 Development and Validation of a Prediction Model for Tube Feeding Dependence after Curative (Chemo-) Radiation in Head and Neck Cancer Wopken, Kim Bijl, Hendrik P. van der Schaaf, Arjen Christianen, Miranda E. Chouvalova, Olga Oosting, Sjoukje F. van der Laan, Bernard F. A. M. Roodenburg, Jan L. N. Leemans, C. René Slotman, Ben J. Doornaert, Patricia Steenbakkers, Roel J. H. M. Verdonck-de Leeuw, Irma M. Langendijk, Johannes A. PLoS One Research Article BACKGROUND: Curative radiotherapy or chemoradiation for head and neck cancer (HNC) may result in severe acute and late side effects, including tube feeding dependence. The purpose of this prospective cohort study was to develop a prediction model for tube feeding dependence 6 months (TUBE(M6)) after curative (chemo-) radiotherapy in HNC patients. PATIENTS AND METHODS: Tube feeding dependence was scored prospectively. To develop the multivariable model, a group LASSO analysis was carried out, with TUBE(M6) as the primary endpoint (n = 427). The model was then validated in a test cohort (n = 183). The training cohort was divided into three groups based on the risk of TUBE(M6) to test whether the model could be extrapolated to later time points (12, 18 and 24 months). RESULTS: Most important predictors for TUBE(M6) were weight loss prior to treatment, advanced T-stage, positive N-stage, bilateral neck irradiation, accelerated radiotherapy and chemoradiation. Model performance was good, with an Area under the Curve of 0.86 in the training cohort and 0.82 in the test cohort. The TUBE(M6)-based risk groups were significantly associated with tube feeding dependence at later time points (p<0.001). CONCLUSION: We established an externally validated predictive model for tube feeding dependence after curative radiotherapy or chemoradiation, which can be used to predict TUBE(M6). Public Library of Science 2014-04-15 /pmc/articles/PMC3988098/ /pubmed/24736318 http://dx.doi.org/10.1371/journal.pone.0094879 Text en © 2014 Wopken et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wopken, Kim
Bijl, Hendrik P.
van der Schaaf, Arjen
Christianen, Miranda E.
Chouvalova, Olga
Oosting, Sjoukje F.
van der Laan, Bernard F. A. M.
Roodenburg, Jan L. N.
Leemans, C. René
Slotman, Ben J.
Doornaert, Patricia
Steenbakkers, Roel J. H. M.
Verdonck-de Leeuw, Irma M.
Langendijk, Johannes A.
Development and Validation of a Prediction Model for Tube Feeding Dependence after Curative (Chemo-) Radiation in Head and Neck Cancer
title Development and Validation of a Prediction Model for Tube Feeding Dependence after Curative (Chemo-) Radiation in Head and Neck Cancer
title_full Development and Validation of a Prediction Model for Tube Feeding Dependence after Curative (Chemo-) Radiation in Head and Neck Cancer
title_fullStr Development and Validation of a Prediction Model for Tube Feeding Dependence after Curative (Chemo-) Radiation in Head and Neck Cancer
title_full_unstemmed Development and Validation of a Prediction Model for Tube Feeding Dependence after Curative (Chemo-) Radiation in Head and Neck Cancer
title_short Development and Validation of a Prediction Model for Tube Feeding Dependence after Curative (Chemo-) Radiation in Head and Neck Cancer
title_sort development and validation of a prediction model for tube feeding dependence after curative (chemo-) radiation in head and neck cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988098/
https://www.ncbi.nlm.nih.gov/pubmed/24736318
http://dx.doi.org/10.1371/journal.pone.0094879
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