Cargando…

Distinct and Overlapping Functions of ptpn11 Genes in Zebrafish Development

The PTPN11 (protein-tyrosine phosphatase, non-receptor type 11) gene encodes SHP2, a cytoplasmic PTP that is essential for vertebrate development. Mutations in PTPN11 are associated with Noonan and LEOPARD syndrome. Human patients with these autosomal dominant disorders display various symptoms, inc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bonetti, Monica, Rodriguez-Martinez, Virginia, Paardekooper Overman, Jeroen, Overvoorde, John, van Eekelen, Mark, Jopling, Chris, den Hertog, Jeroen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988099/ https://www.ncbi.nlm.nih.gov/pubmed/24736444 http://dx.doi.org/10.1371/journal.pone.0094884

Ejemplares similares

Identification and Expression of the Family of Classical Protein-Tyrosine Phosphatases in Zebrafish
por: van Eekelen, Mark, et al.
Publicado: (2010)

Phosphoproteomics-Mediated Identification of Fer Kinase as a Target of Mutant Shp2 in Noonan and LEOPARD Syndrome
por: Paardekooper Overman, Jeroen, et al.
Publicado: (2014)

Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects
por: Runtuwene, Vincent, et al.
Publicado: (2011)

Protein-Tyrosine Kinase Activity Profiling in Knock Down Zebrafish Embryos
por: Lemeer, Simone, et al.
Publicado: (2007)

Shp2 Knockdown and Noonan/LEOPARD Mutant Shp2–Induced Gastrulation Defects
por: Jopling, Chris, et al.
Publicado: (2007)

Pair-Wise Regulation of Convergence and Extension Cell Movements by Four Phosphatases via RhoA
por: van Eekelen, Mark, et al.
Publicado: (2012)

Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development
por: Stumpf, Miriam, et al.
Publicado: (2016)

RPTPα is essential for NCAM-mediated p59(fyn) activation and neurite elongation
por: Bodrikov, Vsevolod, et al.
Publicado: (2005)

Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis
por: Stumpf, Miriam, et al.
Publicado: (2016)

Shp2–Mitogen-Activated Protein Kinase Signaling Drives Proliferation during Zebrafish Embryo Caudal Fin Fold Regeneration
por: Hale, Alexander James, et al.
Publicado: (2018)

Dimerization of Receptor Protein-Tyrosine Phosphatase alpha in living cells
por: Tertoolen, Leon GJ, et al.
Publicado: (2001)

Impaired caudal fin‐fold regeneration in zebrafish deficient for the tumor suppressor Pten
por: Hale, Alexander James, et al.
Publicado: (2017)

Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration
por: Wu, Wei, et al.
Publicado: (2017)

Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma
por: Choorapoikayil, Suma, et al.
Publicado: (2012)

Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish
por: Choorapoikayil, Suma, et al.
Publicado: (2013)

Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses
por: Ventura, Pedro M O, et al.
Publicado: (2022)

Thermal Proteome Profiling in Zebrafish Reveals Effects of Napabucasin on Retinoic Acid Metabolism
por: Leijten, Niels M., et al.
Publicado: (2021)

Curcumin inhibits proliferation of hepatocellular carcinoma cells by blocking PTPN1 and PTPN11 expression
por: Zhang, Jingru, et al.
Publicado: (2023)

Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae
por: Allers, Maaike, et al.
Publicado: (2023)

Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish
por: Hoeksma, Jelmer, et al.
Publicado: (2020)

PTK2 and PTPN11 expression in myelodysplastic syndromes
por: Lazarini, Mariana, et al.
Publicado: (2013)

PTPN11 hypomethylation is associated with gastric cancer progression
por: Xu, Lele, et al.
Publicado: (2020)

Leukemogenic Ptpn11 Allele Causes Defective Erythropoiesis in Mice
por: Usenko, Tatiana, et al.
Publicado: (2014)

Activating Mutations in PTPN11 and KRAS in Canine Histiocytic Sarcomas
por: Takada, Marilia, et al.
Publicado: (2019)

Noonan syndrome: rhGH treatment and PTPN11 mutation
por: Wu, Xian, et al.
Publicado: (2023)

LEOPARD syndrome in an infant with severe hypertrophic cardiomyopathy and PTPN11 mutation
por: Ganigara, Madhusudan, et al.
Publicado: (2011)

Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis
por: Liu, Xia, et al.
Publicado: (2011)

Loss of Ptpn11 (Shp2) drives satellite cells into quiescence
por: Griger, Joscha, et al.
Publicado: (2017)

Teasing apart the multiple roles of Shp2 (Ptpn11) in spermatogenesis
por: Maher, Geoffrey J, et al.
Publicado: (2019)

Cancer risk in patients with Noonan syndrome carrying a PTPN11 mutation
por: Jongmans, Marjolijn C J, et al.
Publicado: (2011)

KRAS Analysis in 34 Noonan Syndrome Patients without PTPN11 Mutation
por: Yamamoto, Kaoru, et al.
Publicado: (2007)

Molecular, clinical, and prognostic implications of PTPN11 mutations in acute myeloid leukemia
por: Fobare, Sydney, et al.
Publicado: (2022)

PTPN11 Gene Mutations and Its Association with the Risk of Congenital Heart Disease
por: Xu, Zi-qing, et al.
Publicado: (2022)

LEOPARD Syndrome with a Sporadic PTPN11 Mutation in a Saudi Patient
por: Alshamrani, Hussein M., et al.
Publicado: (2023)

Ptpn11 Deletion in A Novel Cartilage Cell Causes Metachondromatosis by Activating Hedgehog Signaling
por: Yang, Wentian, et al.
Publicado: (2013)

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
por: Jopling, Chris, et al.
Publicado: (2010)

Loss-of-Function Mutations in PTPN11 Cause Metachondromatosis, but Not Ollier Disease or Maffucci Syndrome
por: Bowen, Margot E., et al.
Publicado: (2011)

A Novel A461S Mutation of PTPN11 in a Female with LEOPARD Syndrome
por: Yoshida, Rie, et al.
Publicado: (2008)

PTPN11 mutation manifesting as LEOPARD syndrome associated with hypertrophic plexi and neuropathic pain
por: Spatola, Marianna, et al.
Publicado: (2015)

An Association of PTPN11 and SHOX Mutations in a Male Presenting With Syndromic Growth Failure
por: Savarese, Emanuela, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3aifq1ronadkfkr7vlc3g1urlb