Control of Established Colon Cancer Xenografts Using a Novel Humanized Single Chain Antibody-Streptococcal Superantigen Fusion Protein Targeting the 5T4 Oncofetal Antigen

Superantigens (SAgs) are microbial toxins that cross-link T cell receptors with major histocompatibility class II (MHC-II) molecules leading to the activation of large numbers of T cells. Herein, we describe the development and preclinical testing of a novel tumor-targeted SAg (TTS) therapeutic buil...

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Detalles Bibliográficos
Autores principales: Patterson, Kelcey G., Dixon Pittaro, Jennifer L., Bastedo, Peter S., Hess, David A., Haeryfar, S. M. Mansour, McCormick, John K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988171/
https://www.ncbi.nlm.nih.gov/pubmed/24736661
http://dx.doi.org/10.1371/journal.pone.0095200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988171/
https://www.ncbi.nlm.nih.gov/pubmed/24736661
http://dx.doi.org/10.1371/journal.pone.0095200

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