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Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1

Long interspersed elements 1 (LINE-1) occupy at least 17% of the human genome and are its only active autonomous retrotransposons. However, the host factors that regulate LINE-1 retrotransposition are not fully understood. Here, we demonstrate that the Aicardi-Goutières syndrome gene product SAMHD1,...

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Detalles Bibliográficos
Autores principales:	Zhao, Ke, Du, Juan, Han, Xue, Goodier, John L., Li, Peng, Zhou, Xiaohong, Wei, Wei, Evans, Sean L., Li, Linzhang, Zhang, Wenyan, Cheung, Ling E., Wang, Guanjun, Kazazian, Haig H., Yu, Xiao-Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988314/ https://www.ncbi.nlm.nih.gov/pubmed/24035396 http://dx.doi.org/10.1016/j.celrep.2013.08.019

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