Role of pancreatic stellate cells in chemoresistance in pancreatic cancer

Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (P...

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Detalles Bibliográficos
Autores principales: McCarroll, Joshua A., Naim, Stephanie, Sharbeen, George, Russia, Nelson, Lee, Julia, Kavallaris, Maria, Goldstein, David, Phillips, Phoebe A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988387/
https://www.ncbi.nlm.nih.gov/pubmed/24782785
http://dx.doi.org/10.3389/fphys.2014.00141
Descripción
Sumario:Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (PSCs) and their interaction with pancreatic cancer cells. As a result of the significant alterations in the tumor microenvironment following activation of PSCs, tumor progression, and chemoresistance is enhanced. This review will discuss how PSCs contribute to chemoresistance in pancreatic cancer.

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