Role of pancreatic stellate cells in chemoresistance in pancreatic cancer

Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (P...

Descripción completa

Detalles Bibliográficos
Autores principales: McCarroll, Joshua A., Naim, Stephanie, Sharbeen, George, Russia, Nelson, Lee, Julia, Kavallaris, Maria, Goldstein, David, Phillips, Phoebe A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988387/
https://www.ncbi.nlm.nih.gov/pubmed/24782785
http://dx.doi.org/10.3389/fphys.2014.00141
_version_ 1782312016235462656
author McCarroll, Joshua A.
Naim, Stephanie
Sharbeen, George
Russia, Nelson
Lee, Julia
Kavallaris, Maria
Goldstein, David
Phillips, Phoebe A.
author_facet McCarroll, Joshua A.
Naim, Stephanie
Sharbeen, George
Russia, Nelson
Lee, Julia
Kavallaris, Maria
Goldstein, David
Phillips, Phoebe A.
author_sort McCarroll, Joshua A.
collection PubMed
description Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (PSCs) and their interaction with pancreatic cancer cells. As a result of the significant alterations in the tumor microenvironment following activation of PSCs, tumor progression, and chemoresistance is enhanced. This review will discuss how PSCs contribute to chemoresistance in pancreatic cancer.
format Online
Article
Text
id pubmed-3988387
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-39883872014-04-29 Role of pancreatic stellate cells in chemoresistance in pancreatic cancer McCarroll, Joshua A. Naim, Stephanie Sharbeen, George Russia, Nelson Lee, Julia Kavallaris, Maria Goldstein, David Phillips, Phoebe A. Front Physiol Physiology Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (PSCs) and their interaction with pancreatic cancer cells. As a result of the significant alterations in the tumor microenvironment following activation of PSCs, tumor progression, and chemoresistance is enhanced. This review will discuss how PSCs contribute to chemoresistance in pancreatic cancer. Frontiers Media S.A. 2014-04-09 /pmc/articles/PMC3988387/ /pubmed/24782785 http://dx.doi.org/10.3389/fphys.2014.00141 Text en Copyright © 2014 McCarroll, Naim, Sharbeen, Russia, Lee, Kavallaris, Goldstein and Phillips. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
McCarroll, Joshua A.
Naim, Stephanie
Sharbeen, George
Russia, Nelson
Lee, Julia
Kavallaris, Maria
Goldstein, David
Phillips, Phoebe A.
Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
title Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
title_full Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
title_fullStr Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
title_full_unstemmed Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
title_short Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
title_sort role of pancreatic stellate cells in chemoresistance in pancreatic cancer
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988387/
https://www.ncbi.nlm.nih.gov/pubmed/24782785
http://dx.doi.org/10.3389/fphys.2014.00141
work_keys_str_mv AT mccarrolljoshuaa roleofpancreaticstellatecellsinchemoresistanceinpancreaticcancer
AT naimstephanie roleofpancreaticstellatecellsinchemoresistanceinpancreaticcancer
AT sharbeengeorge roleofpancreaticstellatecellsinchemoresistanceinpancreaticcancer
AT russianelson roleofpancreaticstellatecellsinchemoresistanceinpancreaticcancer
AT leejulia roleofpancreaticstellatecellsinchemoresistanceinpancreaticcancer
AT kavallarismaria roleofpancreaticstellatecellsinchemoresistanceinpancreaticcancer
AT goldsteindavid roleofpancreaticstellatecellsinchemoresistanceinpancreaticcancer
AT phillipsphoebea roleofpancreaticstellatecellsinchemoresistanceinpancreaticcancer

Ejemplares similares