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Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura
Pulmonary hyalinizing granuloma (PHG) is a rare, benign lung disease of unknown etiology. It manifests as discrete, rounded nodules within the lung parenchyma. A 39-year-old woman presented for investigation after pulmonary nodules were found incidentally. Chest computed tomography showed multiple,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988602/ https://www.ncbi.nlm.nih.gov/pubmed/24744965 http://dx.doi.org/10.4103/2156-7514.127835 |
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author | Coleman, Christopher Nassar, Aziza McComb, Barbara |
author_facet | Coleman, Christopher Nassar, Aziza McComb, Barbara |
author_sort | Coleman, Christopher |
collection | PubMed |
description | Pulmonary hyalinizing granuloma (PHG) is a rare, benign lung disease of unknown etiology. It manifests as discrete, rounded nodules within the lung parenchyma. A 39-year-old woman presented for investigation after pulmonary nodules were found incidentally. Chest computed tomography showed multiple, discrete, non-enhancing pulmonary nodules bilaterally. Positron emission tomography (PET) was negative. Biopsy demonstrated a non-specific lymphoplasmacytic infiltrate. Open resection yielded two nodules consistent with hyalinizing granulomas. The differential for multiple pulmonary nodules is broad. PET scan can help rule out metastatic disease, although some cancers are not hypermetabolic on PET. Furthermore, some non-malignant conditions, including hyalinizing granuloma, can show increased activity on PET. PHG should be included in the differential of multiple pulmonary nodules, especially if nodule stability can be demonstrated and/or needle biopsies are non-diagnostic. Associated immune-mediated conditions, such as idiopathic thrombocytopenic purpura (ITP) in our patient, may also favor HG. In this case report we find an association between PHG and ITP. |
format | Online Article Text |
id | pubmed-3988602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39886022014-04-17 Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura Coleman, Christopher Nassar, Aziza McComb, Barbara J Clin Imaging Sci Case Report Pulmonary hyalinizing granuloma (PHG) is a rare, benign lung disease of unknown etiology. It manifests as discrete, rounded nodules within the lung parenchyma. A 39-year-old woman presented for investigation after pulmonary nodules were found incidentally. Chest computed tomography showed multiple, discrete, non-enhancing pulmonary nodules bilaterally. Positron emission tomography (PET) was negative. Biopsy demonstrated a non-specific lymphoplasmacytic infiltrate. Open resection yielded two nodules consistent with hyalinizing granulomas. The differential for multiple pulmonary nodules is broad. PET scan can help rule out metastatic disease, although some cancers are not hypermetabolic on PET. Furthermore, some non-malignant conditions, including hyalinizing granuloma, can show increased activity on PET. PHG should be included in the differential of multiple pulmonary nodules, especially if nodule stability can be demonstrated and/or needle biopsies are non-diagnostic. Associated immune-mediated conditions, such as idiopathic thrombocytopenic purpura (ITP) in our patient, may also favor HG. In this case report we find an association between PHG and ITP. Medknow Publications & Media Pvt Ltd 2014-02-25 /pmc/articles/PMC3988602/ /pubmed/24744965 http://dx.doi.org/10.4103/2156-7514.127835 Text en Copyright: © 2014 Coleman C. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Case Report Coleman, Christopher Nassar, Aziza McComb, Barbara Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura |
title | Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura |
title_full | Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura |
title_fullStr | Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura |
title_full_unstemmed | Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura |
title_short | Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura |
title_sort | pulmonary hyalinizing granuloma associated with idiopathic thrombocytopenic purpura |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988602/ https://www.ncbi.nlm.nih.gov/pubmed/24744965 http://dx.doi.org/10.4103/2156-7514.127835 |
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