A Case of Secondary Leukemia Subsequent to Myelodysplastic Syndromes Successfully Treated with Azacitidine

Elderly patients with secondary acute myeloid leukemia (AML) following myelodysplastic syndrome (MDS) are often medically unfit for or resistant to chemotherapy, and their prognosis is dismal. In the present paper, we reported a case of secondary leukemia following MDS in an 80-year-old male patient...

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Autores principales: Kumode, Takahiro, Fukui, Ayano, Eguchi, Go, Yamaguchi, Terufumi, Maeda, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988727/
https://www.ncbi.nlm.nih.gov/pubmed/24799912
http://dx.doi.org/10.1155/2014/793928
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author Kumode, Takahiro
Fukui, Ayano
Eguchi, Go
Yamaguchi, Terufumi
Maeda, Yasuhiro
author_facet Kumode, Takahiro
Fukui, Ayano
Eguchi, Go
Yamaguchi, Terufumi
Maeda, Yasuhiro
author_sort Kumode, Takahiro
collection PubMed
description Elderly patients with secondary acute myeloid leukemia (AML) following myelodysplastic syndrome (MDS) are often medically unfit for or resistant to chemotherapy, and their prognosis is dismal. In the present paper, we reported a case of secondary leukemia following MDS in an 80-year-old male patient who was deemed unfit for chemotherapy owing to his old age and poor physical condition. Despite a high tumor burden, treatment with AZA exerted a remarkable response, leading to an immediate cytoreduction in our case. Our results suggest that AZA can be an attractive therapeutic option for elderly MDS or AML patients, offering adequate efficacy and high tolerability.
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spelling pubmed-39887272014-05-05 A Case of Secondary Leukemia Subsequent to Myelodysplastic Syndromes Successfully Treated with Azacitidine Kumode, Takahiro Fukui, Ayano Eguchi, Go Yamaguchi, Terufumi Maeda, Yasuhiro Case Rep Med Case Report Elderly patients with secondary acute myeloid leukemia (AML) following myelodysplastic syndrome (MDS) are often medically unfit for or resistant to chemotherapy, and their prognosis is dismal. In the present paper, we reported a case of secondary leukemia following MDS in an 80-year-old male patient who was deemed unfit for chemotherapy owing to his old age and poor physical condition. Despite a high tumor burden, treatment with AZA exerted a remarkable response, leading to an immediate cytoreduction in our case. Our results suggest that AZA can be an attractive therapeutic option for elderly MDS or AML patients, offering adequate efficacy and high tolerability. Hindawi Publishing Corporation 2014 2014-03-31 /pmc/articles/PMC3988727/ /pubmed/24799912 http://dx.doi.org/10.1155/2014/793928 Text en Copyright © 2014 Takahiro Kumode et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kumode, Takahiro
Fukui, Ayano
Eguchi, Go
Yamaguchi, Terufumi
Maeda, Yasuhiro
A Case of Secondary Leukemia Subsequent to Myelodysplastic Syndromes Successfully Treated with Azacitidine
title A Case of Secondary Leukemia Subsequent to Myelodysplastic Syndromes Successfully Treated with Azacitidine
title_full A Case of Secondary Leukemia Subsequent to Myelodysplastic Syndromes Successfully Treated with Azacitidine
title_fullStr A Case of Secondary Leukemia Subsequent to Myelodysplastic Syndromes Successfully Treated with Azacitidine
title_full_unstemmed A Case of Secondary Leukemia Subsequent to Myelodysplastic Syndromes Successfully Treated with Azacitidine
title_short A Case of Secondary Leukemia Subsequent to Myelodysplastic Syndromes Successfully Treated with Azacitidine
title_sort case of secondary leukemia subsequent to myelodysplastic syndromes successfully treated with azacitidine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988727/
https://www.ncbi.nlm.nih.gov/pubmed/24799912
http://dx.doi.org/10.1155/2014/793928
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