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Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS

Paracetamol (acetaminophen) is a widely used analgesic drug. It interacts with various enzyme families including cytochrome P450 (CYP), cyclooxygenase (COX), and nitric oxide synthase (NOS), and this interplay may produce reactive oxygen species (ROS). We investigated the effects of paracetamol on p...

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Detalles Bibliográficos
Autores principales: Trettin, Arne, Böhmer, Anke, Suchy, Maria-Theresia, Probst, Irmelin, Staerk, Ulrich, Stichtenoth, Dirk O., Frölich, Jürgen C., Tsikas, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988730/
https://www.ncbi.nlm.nih.gov/pubmed/24799980
http://dx.doi.org/10.1155/2014/212576

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