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Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS
Paracetamol (acetaminophen) is a widely used analgesic drug. It interacts with various enzyme families including cytochrome P450 (CYP), cyclooxygenase (COX), and nitric oxide synthase (NOS), and this interplay may produce reactive oxygen species (ROS). We investigated the effects of paracetamol on p...
Autores principales: | Trettin, Arne, Böhmer, Anke, Suchy, Maria-Theresia, Probst, Irmelin, Staerk, Ulrich, Stichtenoth, Dirk O., Frölich, Jürgen C., Tsikas, Dimitrios |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988730/ https://www.ncbi.nlm.nih.gov/pubmed/24799980 http://dx.doi.org/10.1155/2014/212576 |
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