The Menin–Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis

Although CD4 T-cell senescence plays an important role in immunosenescence, the mechanism behind this process remains unclear. Here we show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype...

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Detalles Bibliográficos
Autores principales: Kuwahara, Makoto, Suzuki, Junpei, Tofukuji, Soichi, Yamada, Takeshi, Kanoh, Makoto, Matsumoto, Akira, Maruyama, Saho, Kometani, Kohei, Kurosaki, Tomohiro, Ohara, Osamu, Nakayama, Toshinori, Yamashita, Masakatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988815/
https://www.ncbi.nlm.nih.gov/pubmed/24694524
http://dx.doi.org/10.1038/ncomms4555

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