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Is Contrast Medium Osmolality a Causal Factor for Contrast-Induced Nephropathy?

The exact pathophysiology of contrast-induced nephropathy (CIN) is not fully clarified, yet the osmotic characteristics of contrast media (CM) have been a significant focus in many investigations of CIN. Osmotic effects of CM specific to the kidney include transient decreases in blood flow, filtrati...

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Autores principales: Bucher, Andreas M., De Cecco, Carlo N., Schoepf, U. Joseph, Meinel, Felix G., Krazinski, Aleksander W., Spearman, James V., McQuiston, Andrew D., Wang, Rui, Bucher, Judith, Vogl, Thomas J., Katzberg, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988854/
https://www.ncbi.nlm.nih.gov/pubmed/24800254
http://dx.doi.org/10.1155/2014/931413
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author Bucher, Andreas M.
De Cecco, Carlo N.
Schoepf, U. Joseph
Meinel, Felix G.
Krazinski, Aleksander W.
Spearman, James V.
McQuiston, Andrew D.
Wang, Rui
Bucher, Judith
Vogl, Thomas J.
Katzberg, Richard W.
author_facet Bucher, Andreas M.
De Cecco, Carlo N.
Schoepf, U. Joseph
Meinel, Felix G.
Krazinski, Aleksander W.
Spearman, James V.
McQuiston, Andrew D.
Wang, Rui
Bucher, Judith
Vogl, Thomas J.
Katzberg, Richard W.
author_sort Bucher, Andreas M.
collection PubMed
description The exact pathophysiology of contrast-induced nephropathy (CIN) is not fully clarified, yet the osmotic characteristics of contrast media (CM) have been a significant focus in many investigations of CIN. Osmotic effects of CM specific to the kidney include transient decreases in blood flow, filtration fraction, and glomerular filtration rate. Potentially significant secondary effects include an osmotically induced diuresis with a concomitant dehydrating effect. Clinical experiences that have compared the occurrence of CIN between the various classes of CM based on osmolality have suggested a much less than anticipated advantage, if any, with a lower osmolality. Recent animal experiments actually suggest that induction of a mild osmotic diuresis in association with iso-osmolar agents tends to offset potentially deleterious renal effects of high viscosity-mediated intratubular CM stagnation.
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spelling pubmed-39888542014-05-05 Is Contrast Medium Osmolality a Causal Factor for Contrast-Induced Nephropathy? Bucher, Andreas M. De Cecco, Carlo N. Schoepf, U. Joseph Meinel, Felix G. Krazinski, Aleksander W. Spearman, James V. McQuiston, Andrew D. Wang, Rui Bucher, Judith Vogl, Thomas J. Katzberg, Richard W. Biomed Res Int Review Article The exact pathophysiology of contrast-induced nephropathy (CIN) is not fully clarified, yet the osmotic characteristics of contrast media (CM) have been a significant focus in many investigations of CIN. Osmotic effects of CM specific to the kidney include transient decreases in blood flow, filtration fraction, and glomerular filtration rate. Potentially significant secondary effects include an osmotically induced diuresis with a concomitant dehydrating effect. Clinical experiences that have compared the occurrence of CIN between the various classes of CM based on osmolality have suggested a much less than anticipated advantage, if any, with a lower osmolality. Recent animal experiments actually suggest that induction of a mild osmotic diuresis in association with iso-osmolar agents tends to offset potentially deleterious renal effects of high viscosity-mediated intratubular CM stagnation. Hindawi Publishing Corporation 2014 2014-03-31 /pmc/articles/PMC3988854/ /pubmed/24800254 http://dx.doi.org/10.1155/2014/931413 Text en Copyright © 2014 Andreas M. Bucher et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bucher, Andreas M.
De Cecco, Carlo N.
Schoepf, U. Joseph
Meinel, Felix G.
Krazinski, Aleksander W.
Spearman, James V.
McQuiston, Andrew D.
Wang, Rui
Bucher, Judith
Vogl, Thomas J.
Katzberg, Richard W.
Is Contrast Medium Osmolality a Causal Factor for Contrast-Induced Nephropathy?
title Is Contrast Medium Osmolality a Causal Factor for Contrast-Induced Nephropathy?
title_full Is Contrast Medium Osmolality a Causal Factor for Contrast-Induced Nephropathy?
title_fullStr Is Contrast Medium Osmolality a Causal Factor for Contrast-Induced Nephropathy?
title_full_unstemmed Is Contrast Medium Osmolality a Causal Factor for Contrast-Induced Nephropathy?
title_short Is Contrast Medium Osmolality a Causal Factor for Contrast-Induced Nephropathy?
title_sort is contrast medium osmolality a causal factor for contrast-induced nephropathy?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988854/
https://www.ncbi.nlm.nih.gov/pubmed/24800254
http://dx.doi.org/10.1155/2014/931413
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