Oncogenic RET Kinase Domain Mutations Perturb the Autophosphorylation Trajectory by Enhancing Substrate Presentation In trans

To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry. Early autophosphorylation sites map to regions flanking the kinase domain core, while sites within the activ...

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Detalles Bibliográficos
Autores principales: Plaza-Menacho, Iván, Barnouin, Karin, Goodman, Kerry, Martínez-Torres, Rubén J., Borg, Annabel, Murray-Rust, Judith, Mouilleron, Stephane, Knowles, Phillip, McDonald, Neil Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988870/
https://www.ncbi.nlm.nih.gov/pubmed/24560924
http://dx.doi.org/10.1016/j.molcel.2014.01.015

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