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MICU1 and MICU2 Finely Tune the Mitochondrial Ca(2+) Uniporter by Exerting Opposite Effects on MCU Activity
Mitochondrial calcium accumulation was recently shown to depend on a complex composed of an inner-membrane channel (MCU and MCUb) and regulatory subunits (MICU1, MCUR1, and EMRE). A fundamental property of MCU is low activity at resting cytosolic Ca(2+) concentrations, preventing deleterious Ca(2+)...
Autores principales: | Patron, Maria, Checchetto, Vanessa, Raffaello, Anna, Teardo, Enrico, Vecellio Reane, Denis, Mantoan, Maura, Granatiero, Veronica, Szabò, Ildikò, De Stefani, Diego, Rizzuto, Rosario |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988891/ https://www.ncbi.nlm.nih.gov/pubmed/24560927 http://dx.doi.org/10.1016/j.molcel.2014.01.013 |
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