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Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis

There are no European recommendations on issues specifically related to lung transplantation (LTX) in cystic fibrosis (CF). The main goal of this paper is to provide CF care team members with clinically relevant CF-specific information on all aspects of LTX, highlighting areas of consensus and contr...

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Autores principales: Hirche, T. O., Knoop, C., Hebestreit, H., Shimmin, D., Solé, A., Elborn, J. S., Ellemunter, H., Aurora, P., Hogardt, M., Wagner, T. O. F., ECORN-CF Study Group
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988894/
https://www.ncbi.nlm.nih.gov/pubmed/24800072
http://dx.doi.org/10.1155/2014/621342
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author Hirche, T. O.
Knoop, C.
Hebestreit, H.
Shimmin, D.
Solé, A.
Elborn, J. S.
Ellemunter, H.
Aurora, P.
Hogardt, M.
Wagner, T. O. F.
ECORN-CF Study Group,
author_facet Hirche, T. O.
Knoop, C.
Hebestreit, H.
Shimmin, D.
Solé, A.
Elborn, J. S.
Ellemunter, H.
Aurora, P.
Hogardt, M.
Wagner, T. O. F.
ECORN-CF Study Group,
author_sort Hirche, T. O.
collection PubMed
description There are no European recommendations on issues specifically related to lung transplantation (LTX) in cystic fibrosis (CF). The main goal of this paper is to provide CF care team members with clinically relevant CF-specific information on all aspects of LTX, highlighting areas of consensus and controversy throughout Europe. Bilateral lung transplantation has been shown to be an important therapeutic option for end-stage CF pulmonary disease. Transplant function and patient survival after transplantation are better than in most other indications for this procedure. Attention though has to be paid to pretransplant morbidity, time for referral, evaluation, indication, and contraindication in children and in adults. This review makes extensive use of specific evidence in the field of lung transplantation in CF patients and addresses all issues of practical importance. The requirements of pre-, peri-, and postoperative management are discussed in detail including bridging to transplant and postoperative complications, immune suppression, chronic allograft dysfunction, infection, and malignancies being the most important. Among the contributors to this guiding information are 19 members of the ECORN-CF project and other experts. The document is endorsed by the European Cystic Fibrosis Society and sponsored by the Christiane Herzog Foundation.
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spelling pubmed-39888942014-05-05 Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis Hirche, T. O. Knoop, C. Hebestreit, H. Shimmin, D. Solé, A. Elborn, J. S. Ellemunter, H. Aurora, P. Hogardt, M. Wagner, T. O. F. ECORN-CF Study Group, Pulm Med Review Article There are no European recommendations on issues specifically related to lung transplantation (LTX) in cystic fibrosis (CF). The main goal of this paper is to provide CF care team members with clinically relevant CF-specific information on all aspects of LTX, highlighting areas of consensus and controversy throughout Europe. Bilateral lung transplantation has been shown to be an important therapeutic option for end-stage CF pulmonary disease. Transplant function and patient survival after transplantation are better than in most other indications for this procedure. Attention though has to be paid to pretransplant morbidity, time for referral, evaluation, indication, and contraindication in children and in adults. This review makes extensive use of specific evidence in the field of lung transplantation in CF patients and addresses all issues of practical importance. The requirements of pre-, peri-, and postoperative management are discussed in detail including bridging to transplant and postoperative complications, immune suppression, chronic allograft dysfunction, infection, and malignancies being the most important. Among the contributors to this guiding information are 19 members of the ECORN-CF project and other experts. The document is endorsed by the European Cystic Fibrosis Society and sponsored by the Christiane Herzog Foundation. Hindawi Publishing Corporation 2014 2014-03-30 /pmc/articles/PMC3988894/ /pubmed/24800072 http://dx.doi.org/10.1155/2014/621342 Text en Copyright © 2014 T. O. Hirche et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hirche, T. O.
Knoop, C.
Hebestreit, H.
Shimmin, D.
Solé, A.
Elborn, J. S.
Ellemunter, H.
Aurora, P.
Hogardt, M.
Wagner, T. O. F.
ECORN-CF Study Group,
Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis
title Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis
title_full Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis
title_fullStr Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis
title_full_unstemmed Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis
title_short Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis
title_sort practical guidelines: lung transplantation in patients with cystic fibrosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988894/
https://www.ncbi.nlm.nih.gov/pubmed/24800072
http://dx.doi.org/10.1155/2014/621342
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