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An Overview of Fotemustine in High-Grade Gliomas: From Single Agent to Association with Bevacizumab

Fotemustine is a third-generation nitrosourea showing efficacy in various types of tumors such as melanoma and glioma. We reviewed the most important studies on fotemustine treatment in glioma patients analyzing its pharmacological profile and its activity and safety. Fotemustine was used as single...

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Autores principales: Lombardi, Giuseppe, Farina, Patrizia, Della Puppa, Alessandro, Cecchin, Diego, Pambuku, Ardi, Bellu, Luisa, Zagonel, Vittorina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988896/
https://www.ncbi.nlm.nih.gov/pubmed/24800248
http://dx.doi.org/10.1155/2014/698542
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author Lombardi, Giuseppe
Farina, Patrizia
Della Puppa, Alessandro
Cecchin, Diego
Pambuku, Ardi
Bellu, Luisa
Zagonel, Vittorina
author_facet Lombardi, Giuseppe
Farina, Patrizia
Della Puppa, Alessandro
Cecchin, Diego
Pambuku, Ardi
Bellu, Luisa
Zagonel, Vittorina
author_sort Lombardi, Giuseppe
collection PubMed
description Fotemustine is a third-generation nitrosourea showing efficacy in various types of tumors such as melanoma and glioma. We reviewed the most important studies on fotemustine treatment in glioma patients analyzing its pharmacological profile and its activity and safety. Fotemustine was used as single agent or in association with new targeted drugs such as bevacizumab; fotemustine was used both as first-line chemotherapy before temozolomide era and in refractory-temozolomide patients during temozolomide era. Finally, analyzing and comparing the activity and safety of fotemustine alone or in combination with bevacizumab versus other nitrosoureas such as lomustine, we may suggest that the combination treatment with bevacizumab and fotemustine may be active and tolerable in patients with high grade gliomas.
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spelling pubmed-39888962014-05-05 An Overview of Fotemustine in High-Grade Gliomas: From Single Agent to Association with Bevacizumab Lombardi, Giuseppe Farina, Patrizia Della Puppa, Alessandro Cecchin, Diego Pambuku, Ardi Bellu, Luisa Zagonel, Vittorina Biomed Res Int Review Article Fotemustine is a third-generation nitrosourea showing efficacy in various types of tumors such as melanoma and glioma. We reviewed the most important studies on fotemustine treatment in glioma patients analyzing its pharmacological profile and its activity and safety. Fotemustine was used as single agent or in association with new targeted drugs such as bevacizumab; fotemustine was used both as first-line chemotherapy before temozolomide era and in refractory-temozolomide patients during temozolomide era. Finally, analyzing and comparing the activity and safety of fotemustine alone or in combination with bevacizumab versus other nitrosoureas such as lomustine, we may suggest that the combination treatment with bevacizumab and fotemustine may be active and tolerable in patients with high grade gliomas. Hindawi Publishing Corporation 2014 2014-03-31 /pmc/articles/PMC3988896/ /pubmed/24800248 http://dx.doi.org/10.1155/2014/698542 Text en Copyright © 2014 Giuseppe Lombardi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lombardi, Giuseppe
Farina, Patrizia
Della Puppa, Alessandro
Cecchin, Diego
Pambuku, Ardi
Bellu, Luisa
Zagonel, Vittorina
An Overview of Fotemustine in High-Grade Gliomas: From Single Agent to Association with Bevacizumab
title An Overview of Fotemustine in High-Grade Gliomas: From Single Agent to Association with Bevacizumab
title_full An Overview of Fotemustine in High-Grade Gliomas: From Single Agent to Association with Bevacizumab
title_fullStr An Overview of Fotemustine in High-Grade Gliomas: From Single Agent to Association with Bevacizumab
title_full_unstemmed An Overview of Fotemustine in High-Grade Gliomas: From Single Agent to Association with Bevacizumab
title_short An Overview of Fotemustine in High-Grade Gliomas: From Single Agent to Association with Bevacizumab
title_sort overview of fotemustine in high-grade gliomas: from single agent to association with bevacizumab
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988896/
https://www.ncbi.nlm.nih.gov/pubmed/24800248
http://dx.doi.org/10.1155/2014/698542
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