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Selective ALDH3A1 Inhibition by Benzimidazole Analogues Increase Mafosfamide Sensitivity in Cancer Cells

[Image: see text] Aldehyde dehydrogenase enzymes irreversibly oxidize aldehydes generated from metabolism of amino acids, fatty acids, food, smoke, additives, and xenobiotic drugs. Cyclophosphamide is one such xenobiotic used in cancer therapies. Upon activation, cyclophosphamide forms an intermedia...

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Detalles Bibliográficos
Autores principales:	Parajuli, Bibek, Fishel, Melissa L., Hurley, Thomas D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988914/ https://www.ncbi.nlm.nih.gov/pubmed/24387105 http://dx.doi.org/10.1021/jm401508p

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