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The Evaluation of Red Cell Distribution Width in Chronic Hemodialysis Patients

Background. Red cell distribution width (RDW) has been used as a marker of iron deficiency; however, it is accepted as a marker of cardiovascular survival. We aimed to study RDW levels in hemodialysis (HD) patients and the association between RDW and inflammatory, nutritional, and volume markers. Me...

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Autores principales: Tekce, Hikmet, Kin Tekce, Buket, Aktas, Gulali, Tanrisev, Mehmet, Sit, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988915/
https://www.ncbi.nlm.nih.gov/pubmed/24800077
http://dx.doi.org/10.1155/2014/754370
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author Tekce, Hikmet
Kin Tekce, Buket
Aktas, Gulali
Tanrisev, Mehmet
Sit, Mustafa
author_facet Tekce, Hikmet
Kin Tekce, Buket
Aktas, Gulali
Tanrisev, Mehmet
Sit, Mustafa
author_sort Tekce, Hikmet
collection PubMed
description Background. Red cell distribution width (RDW) has been used as a marker of iron deficiency; however, it is accepted as a marker of cardiovascular survival. We aimed to study RDW levels in hemodialysis (HD) patients and the association between RDW and inflammatory, nutritional, and volume markers. Methods. We included 296 HD patients with sufficient iron storage and without anemia or hypervolemia. We grouped patients into four groups according to clinical parameters, albumin, and C-reactive protein (CRP). Results. The lowest RDW levels were found in group 1 (13.2%). Although RDW of group 2 was higher than that of group 1, it was still in normal range (14.7% versus 13.2%, P = 0.028). RDW levels of groups 3 (17.8%) and 4 (18.5%) were significantly higher than those of groups 1 and 2 and above normal range. A positive correlation was detected between RDW and HD duration, interdialytic weight gain (IDWG), serum phosphate, and CRP levels and a negative correlation was detected with serum albumin. HD duration, CRP, IDWG, and serum albumin have been found as independent predictors of RDW elevation. Conclusions. Results of the present study reflect adverse effects of inflammation, malnutrition, and excess IDWG on RDW elevation in an HD study cohort with sufficient iron storage and without anemia and hypervolemia.
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spelling pubmed-39889152014-05-05 The Evaluation of Red Cell Distribution Width in Chronic Hemodialysis Patients Tekce, Hikmet Kin Tekce, Buket Aktas, Gulali Tanrisev, Mehmet Sit, Mustafa Int J Nephrol Research Article Background. Red cell distribution width (RDW) has been used as a marker of iron deficiency; however, it is accepted as a marker of cardiovascular survival. We aimed to study RDW levels in hemodialysis (HD) patients and the association between RDW and inflammatory, nutritional, and volume markers. Methods. We included 296 HD patients with sufficient iron storage and without anemia or hypervolemia. We grouped patients into four groups according to clinical parameters, albumin, and C-reactive protein (CRP). Results. The lowest RDW levels were found in group 1 (13.2%). Although RDW of group 2 was higher than that of group 1, it was still in normal range (14.7% versus 13.2%, P = 0.028). RDW levels of groups 3 (17.8%) and 4 (18.5%) were significantly higher than those of groups 1 and 2 and above normal range. A positive correlation was detected between RDW and HD duration, interdialytic weight gain (IDWG), serum phosphate, and CRP levels and a negative correlation was detected with serum albumin. HD duration, CRP, IDWG, and serum albumin have been found as independent predictors of RDW elevation. Conclusions. Results of the present study reflect adverse effects of inflammation, malnutrition, and excess IDWG on RDW elevation in an HD study cohort with sufficient iron storage and without anemia and hypervolemia. Hindawi Publishing Corporation 2014 2014-03-30 /pmc/articles/PMC3988915/ /pubmed/24800077 http://dx.doi.org/10.1155/2014/754370 Text en Copyright © 2014 Hikmet Tekce et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tekce, Hikmet
Kin Tekce, Buket
Aktas, Gulali
Tanrisev, Mehmet
Sit, Mustafa
The Evaluation of Red Cell Distribution Width in Chronic Hemodialysis Patients
title The Evaluation of Red Cell Distribution Width in Chronic Hemodialysis Patients
title_full The Evaluation of Red Cell Distribution Width in Chronic Hemodialysis Patients
title_fullStr The Evaluation of Red Cell Distribution Width in Chronic Hemodialysis Patients
title_full_unstemmed The Evaluation of Red Cell Distribution Width in Chronic Hemodialysis Patients
title_short The Evaluation of Red Cell Distribution Width in Chronic Hemodialysis Patients
title_sort evaluation of red cell distribution width in chronic hemodialysis patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988915/
https://www.ncbi.nlm.nih.gov/pubmed/24800077
http://dx.doi.org/10.1155/2014/754370
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