Introduction of Aromatic Ring-Containing Substituents in Cyclic Nucleotides Is Associated with Inhibition of Toxin Uptake by the Hepatocyte Transporters OATP 1B1 and 1B3

Analogs of the cyclic nucleotides cAMP and cGMP have been extensively used to mimic or modulate cellular events mediated by protein kinase A (PKA), Exchange protein directly activated by cAMP (Epac), or protein kinase G (PKG). We report here that some of the most commonly used cyclic nucleotide anal...

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Detalles Bibliográficos
Autores principales: Herfindal, Lars, Krakstad, Camilla, Myhren, Lene, Hagland, Hanne, Kopperud, Reidun, Teigen, Knut, Schwede, Frank, Kleppe, Rune, Døskeland, Stein Ove
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989234/
https://www.ncbi.nlm.nih.gov/pubmed/24740327
http://dx.doi.org/10.1371/journal.pone.0094926

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