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Exploring the Influence of EGCG on the β-Sheet-Rich Oligomers of Human Islet Amyloid Polypeptide (hIAPP(1–37)) and Identifying Its Possible Binding Sites from Molecular Dynamics Simulation

EGCG possesses the ability of disaggregating the existing amyloid fibrils which were associated with many age-related degenerative diseases. However, the molecular mechanism of EGCG to disaggregate these fibrils is poorly known. In this work, to study the influence of EGCG on the full-length human i...

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Detalles Bibliográficos
Autores principales:	Wang, Qianqian, Guo, Jingjing, Jiao, Pingzu, Liu, Huanxiang, Yao, Xiaojun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989243/ https://www.ncbi.nlm.nih.gov/pubmed/24739876 http://dx.doi.org/10.1371/journal.pone.0094796

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