Sonic Hedgehog Activation Is Implicated in Diosgenin-Induced Megakaryocytic Differentiation of Human Erythroleukemia Cells

Differentiation therapy is a means to treat cancer and is induced by different agents with low toxicity and more specificity than traditional ones. Diosgenin, a plant steroid, is able to induce megakaryocytic differentiation or apoptosis in human HEL erythroleukemia cells in a dose-dependent manner....

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Detalles Bibliográficos
Autores principales: Ghezali, Lamia, Liagre, Bertrand, Limami, Youness, Beneytout, Jean-Louis, Leger, David Yannick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989280/
https://www.ncbi.nlm.nih.gov/pubmed/24740159
http://dx.doi.org/10.1371/journal.pone.0095016

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