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Association between the Epidermal Growth Factor +61G/A Polymorphism and Glioma Risk: A Meta-Analysis
BACKGROUND: Gliomas account for almost 80% of primary malignant brain tumors. Epidermal growth factor (EGF) is an interesting research candidate in which to look for genetic polymorphisms because of its role in mitogenesis and proliferation. Extensive studies have found that a single nucleotide poly...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989292/ https://www.ncbi.nlm.nih.gov/pubmed/24740103 http://dx.doi.org/10.1371/journal.pone.0095139 |
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author | Chen, Xin Yang, Guang Zhang, Daming Zhang, Weiguang Zou, Huichao Zhao, Hongbo Zhang, Xinjian Zhao, Shiguang |
author_facet | Chen, Xin Yang, Guang Zhang, Daming Zhang, Weiguang Zou, Huichao Zhao, Hongbo Zhang, Xinjian Zhao, Shiguang |
author_sort | Chen, Xin |
collection | PubMed |
description | BACKGROUND: Gliomas account for almost 80% of primary malignant brain tumors. Epidermal growth factor (EGF) is an interesting research candidate in which to look for genetic polymorphisms because of its role in mitogenesis and proliferation. Extensive studies have found that a single nucleotide polymorphism (SNP) +61G/A (rs4444903) in the EGF gene is associated with the susceptibility of glioma, however, the results have been controversial. Furthermore, the association between EGF +61G/A polymorphism with the development and grade progress of glioma has not been established. METHODS: We examined the association of EGF +61G/A polymorphism and glioma by performing a meta-analysis. Nine studies testing the associations between EGF +61G/A polymorphism and risk of glioma with 1758 cases and 2823 controls were retrieved. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. The pooled ORs were performed for the allele model, codominant model, dominant model, and recessive model, respectively. RESULTS: Overall, this meta-analysis showed significant associations between the EGF +61G/A polymorphism and glioma susceptibility in all four genetic models. However, in the stratified analysis by the grade of glioma, we only found this association existed in patients with Grade IV glioblastoma, but not in patients with Grade I-III glioma. We further compared EGF +61G/A polymorphism in patients with glioblastoma and Grade I-III glioma accordingly, the stronger association between the EGF +61G/A polymorphism and the malignancy of glioma was found. CONCLUSIONS: The results of this meta-analysis suggested that the EGF +61G/A polymorphism is associated with both the susceptibility of glioma and the malignance of glioma. |
format | Online Article Text |
id | pubmed-3989292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39892922014-04-21 Association between the Epidermal Growth Factor +61G/A Polymorphism and Glioma Risk: A Meta-Analysis Chen, Xin Yang, Guang Zhang, Daming Zhang, Weiguang Zou, Huichao Zhao, Hongbo Zhang, Xinjian Zhao, Shiguang PLoS One Research Article BACKGROUND: Gliomas account for almost 80% of primary malignant brain tumors. Epidermal growth factor (EGF) is an interesting research candidate in which to look for genetic polymorphisms because of its role in mitogenesis and proliferation. Extensive studies have found that a single nucleotide polymorphism (SNP) +61G/A (rs4444903) in the EGF gene is associated with the susceptibility of glioma, however, the results have been controversial. Furthermore, the association between EGF +61G/A polymorphism with the development and grade progress of glioma has not been established. METHODS: We examined the association of EGF +61G/A polymorphism and glioma by performing a meta-analysis. Nine studies testing the associations between EGF +61G/A polymorphism and risk of glioma with 1758 cases and 2823 controls were retrieved. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. The pooled ORs were performed for the allele model, codominant model, dominant model, and recessive model, respectively. RESULTS: Overall, this meta-analysis showed significant associations between the EGF +61G/A polymorphism and glioma susceptibility in all four genetic models. However, in the stratified analysis by the grade of glioma, we only found this association existed in patients with Grade IV glioblastoma, but not in patients with Grade I-III glioma. We further compared EGF +61G/A polymorphism in patients with glioblastoma and Grade I-III glioma accordingly, the stronger association between the EGF +61G/A polymorphism and the malignancy of glioma was found. CONCLUSIONS: The results of this meta-analysis suggested that the EGF +61G/A polymorphism is associated with both the susceptibility of glioma and the malignance of glioma. Public Library of Science 2014-04-16 /pmc/articles/PMC3989292/ /pubmed/24740103 http://dx.doi.org/10.1371/journal.pone.0095139 Text en © 2014 Chen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chen, Xin Yang, Guang Zhang, Daming Zhang, Weiguang Zou, Huichao Zhao, Hongbo Zhang, Xinjian Zhao, Shiguang Association between the Epidermal Growth Factor +61G/A Polymorphism and Glioma Risk: A Meta-Analysis |
title | Association between the Epidermal Growth Factor +61G/A Polymorphism and Glioma Risk: A Meta-Analysis |
title_full | Association between the Epidermal Growth Factor +61G/A Polymorphism and Glioma Risk: A Meta-Analysis |
title_fullStr | Association between the Epidermal Growth Factor +61G/A Polymorphism and Glioma Risk: A Meta-Analysis |
title_full_unstemmed | Association between the Epidermal Growth Factor +61G/A Polymorphism and Glioma Risk: A Meta-Analysis |
title_short | Association between the Epidermal Growth Factor +61G/A Polymorphism and Glioma Risk: A Meta-Analysis |
title_sort | association between the epidermal growth factor +61g/a polymorphism and glioma risk: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989292/ https://www.ncbi.nlm.nih.gov/pubmed/24740103 http://dx.doi.org/10.1371/journal.pone.0095139 |
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