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Acute Moderate Exercise Does Not Further Alter the Autonomic Nervous System Activity in Patients with Sickle Cell Anemia

A decreased global autonomic nervous system (ANS) activity and increased sympathetic activation in patients with sickle cell anemia (SCA) seem to worsen the clinical severity and could play a role in the pathophysiology of the disease, notably by triggering vaso-occlusive crises. Because exercise ch...

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Autores principales: Hedreville, Mona, Charlot, Keyne, Waltz, Xavier, Sinnapah, Stéphane, Lemonne, Nathalie, Etienne-Julan, Maryse, Soter, Valérie, Hue, Olivier, Hardy-Dessources, Marie-Dominique, Barthélémy, Jean-Claude, Connes, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989338/
https://www.ncbi.nlm.nih.gov/pubmed/24740295
http://dx.doi.org/10.1371/journal.pone.0095563
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author Hedreville, Mona
Charlot, Keyne
Waltz, Xavier
Sinnapah, Stéphane
Lemonne, Nathalie
Etienne-Julan, Maryse
Soter, Valérie
Hue, Olivier
Hardy-Dessources, Marie-Dominique
Barthélémy, Jean-Claude
Connes, Philippe
author_facet Hedreville, Mona
Charlot, Keyne
Waltz, Xavier
Sinnapah, Stéphane
Lemonne, Nathalie
Etienne-Julan, Maryse
Soter, Valérie
Hue, Olivier
Hardy-Dessources, Marie-Dominique
Barthélémy, Jean-Claude
Connes, Philippe
author_sort Hedreville, Mona
collection PubMed
description A decreased global autonomic nervous system (ANS) activity and increased sympathetic activation in patients with sickle cell anemia (SCA) seem to worsen the clinical severity and could play a role in the pathophysiology of the disease, notably by triggering vaso-occlusive crises. Because exercise challenges the ANS activity in the general population, we sought to determine whether a short (<15 min) and progressive moderate exercise session conducted until the first ventilatory threshold had an effect on the ANS activity of a group of SCA patients and a group of healthy individuals (CONT group). Temporal and spectral analyses of the nocturnal heart rate variability were performed before and on the 3 nights following the exercise session. Standard deviation of all normal RR intervals (SDNN), total power, low frequencies (LF) and high frequencies powers (HF) were lower but LF/HF was higher in SCA patients than in the CONT group. Moderate exercise did not modify ANS activity in both groups. In addition, no adverse clinical events occurred during the entire protocol. These results imply that this kind of short and moderate exercise is not detrimental for SCA patients.
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spelling pubmed-39893382014-04-21 Acute Moderate Exercise Does Not Further Alter the Autonomic Nervous System Activity in Patients with Sickle Cell Anemia Hedreville, Mona Charlot, Keyne Waltz, Xavier Sinnapah, Stéphane Lemonne, Nathalie Etienne-Julan, Maryse Soter, Valérie Hue, Olivier Hardy-Dessources, Marie-Dominique Barthélémy, Jean-Claude Connes, Philippe PLoS One Research Article A decreased global autonomic nervous system (ANS) activity and increased sympathetic activation in patients with sickle cell anemia (SCA) seem to worsen the clinical severity and could play a role in the pathophysiology of the disease, notably by triggering vaso-occlusive crises. Because exercise challenges the ANS activity in the general population, we sought to determine whether a short (<15 min) and progressive moderate exercise session conducted until the first ventilatory threshold had an effect on the ANS activity of a group of SCA patients and a group of healthy individuals (CONT group). Temporal and spectral analyses of the nocturnal heart rate variability were performed before and on the 3 nights following the exercise session. Standard deviation of all normal RR intervals (SDNN), total power, low frequencies (LF) and high frequencies powers (HF) were lower but LF/HF was higher in SCA patients than in the CONT group. Moderate exercise did not modify ANS activity in both groups. In addition, no adverse clinical events occurred during the entire protocol. These results imply that this kind of short and moderate exercise is not detrimental for SCA patients. Public Library of Science 2014-04-16 /pmc/articles/PMC3989338/ /pubmed/24740295 http://dx.doi.org/10.1371/journal.pone.0095563 Text en © 2014 Hedreville et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hedreville, Mona
Charlot, Keyne
Waltz, Xavier
Sinnapah, Stéphane
Lemonne, Nathalie
Etienne-Julan, Maryse
Soter, Valérie
Hue, Olivier
Hardy-Dessources, Marie-Dominique
Barthélémy, Jean-Claude
Connes, Philippe
Acute Moderate Exercise Does Not Further Alter the Autonomic Nervous System Activity in Patients with Sickle Cell Anemia
title Acute Moderate Exercise Does Not Further Alter the Autonomic Nervous System Activity in Patients with Sickle Cell Anemia
title_full Acute Moderate Exercise Does Not Further Alter the Autonomic Nervous System Activity in Patients with Sickle Cell Anemia
title_fullStr Acute Moderate Exercise Does Not Further Alter the Autonomic Nervous System Activity in Patients with Sickle Cell Anemia
title_full_unstemmed Acute Moderate Exercise Does Not Further Alter the Autonomic Nervous System Activity in Patients with Sickle Cell Anemia
title_short Acute Moderate Exercise Does Not Further Alter the Autonomic Nervous System Activity in Patients with Sickle Cell Anemia
title_sort acute moderate exercise does not further alter the autonomic nervous system activity in patients with sickle cell anemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989338/
https://www.ncbi.nlm.nih.gov/pubmed/24740295
http://dx.doi.org/10.1371/journal.pone.0095563
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