Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons

Survival of adult-born hippocampal granule cells is modulated by neural activity, and thought to be enhanced by excitatory synaptic signaling. Here, we report that a reduction in the synaptogenic protein neuroligin-1 in adult-born neurons in vivo decreased their survival, but surprisingly, this effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Schnell, Eric, Long, Thomas H., Bensen, AeSoon L., Washburn, Eric K., Westbrook, Gary L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989658/
https://www.ncbi.nlm.nih.gov/pubmed/24782702
http://dx.doi.org/10.3389/fnins.2014.00071
_version_ 1782312176973774848
author Schnell, Eric
Long, Thomas H.
Bensen, AeSoon L.
Washburn, Eric K.
Westbrook, Gary L.
author_facet Schnell, Eric
Long, Thomas H.
Bensen, AeSoon L.
Washburn, Eric K.
Westbrook, Gary L.
author_sort Schnell, Eric
collection PubMed
description Survival of adult-born hippocampal granule cells is modulated by neural activity, and thought to be enhanced by excitatory synaptic signaling. Here, we report that a reduction in the synaptogenic protein neuroligin-1 in adult-born neurons in vivo decreased their survival, but surprisingly, this effect was independent of changes in excitatory synaptic function. Instead, the decreased survival was associated with unexpected changes in dendrite and spine morphology during granule cell maturation, suggesting a link between cell growth and survival.
format Online
Article
Text
id pubmed-3989658
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-39896582014-04-29 Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons Schnell, Eric Long, Thomas H. Bensen, AeSoon L. Washburn, Eric K. Westbrook, Gary L. Front Neurosci Neuroscience Survival of adult-born hippocampal granule cells is modulated by neural activity, and thought to be enhanced by excitatory synaptic signaling. Here, we report that a reduction in the synaptogenic protein neuroligin-1 in adult-born neurons in vivo decreased their survival, but surprisingly, this effect was independent of changes in excitatory synaptic function. Instead, the decreased survival was associated with unexpected changes in dendrite and spine morphology during granule cell maturation, suggesting a link between cell growth and survival. Frontiers Media S.A. 2014-04-10 /pmc/articles/PMC3989658/ /pubmed/24782702 http://dx.doi.org/10.3389/fnins.2014.00071 Text en Copyright © 2014 Schnell, Long, Bensen, Washburn and Westbrook. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Schnell, Eric
Long, Thomas H.
Bensen, AeSoon L.
Washburn, Eric K.
Westbrook, Gary L.
Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons
title Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons
title_full Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons
title_fullStr Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons
title_full_unstemmed Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons
title_short Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons
title_sort neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989658/
https://www.ncbi.nlm.nih.gov/pubmed/24782702
http://dx.doi.org/10.3389/fnins.2014.00071
work_keys_str_mv AT schnelleric neuroligin1knockdownreducessurvivalofadultgeneratednewbornhippocampalneurons
AT longthomash neuroligin1knockdownreducessurvivalofadultgeneratednewbornhippocampalneurons
AT bensenaesoonl neuroligin1knockdownreducessurvivalofadultgeneratednewbornhippocampalneurons
AT washburnerick neuroligin1knockdownreducessurvivalofadultgeneratednewbornhippocampalneurons
AT westbrookgaryl neuroligin1knockdownreducessurvivalofadultgeneratednewbornhippocampalneurons

Ejemplares similares